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PROSITE documentation PDOC00806

YjeF C-terminal domain signatures and profile


The YjeF C-terminal domain is an ~280-residue module found in the following proteins:

  • Yeast chromosome XI hypothetical protein YKL151c.
  • Caenorhabditis elegans hypothetical protein R107.2.
  • Escherichia coli hypothetical protein YjeF.
  • Bacillus subtilis hypothetical protein yxkO.
  • Helicobacter pylori hypothetical protein HP1363.
  • Mycobacterium tuberculosis hypothetical protein MtCY77.05c.
  • Mycobacterium leprae hypothetical protein B229_C2_201.
  • Synechocystis strain PCC 6803 hypothetical protein sll1433.
  • Methanococcus jannaschii hypothetical protein MJ1586.
  • Streptococcus mutans putative uncharacterized protein SMU.573.
  • Streptococcus thermophilus predicted sugar kinase STER_0661.
  • Streptococcus sanguinis putative uncharacterized protein SSA_0673.
  • Thermotoga maritima hypothetical protein Tm0922.

The YjeF C-terminal domain has an α/β fold and shows high structural homology to the members of a ribokinase-like superfamily. The members of the ribokinase-like superfamily are all phosphotransferases and catalyze the phosphorylation of the hydroxymethyl group of the substrate; magnesium and ATP (or ADP) are required for their activity. The YjeF C-terminal is found in association with the YjeF N-terminal domain, which belongs of a specialized family of Rossmann fold domains (see <PDOC51385>) [1,2,3].

The first pattern we developed covers residues that might be involved in forming the substrate-binding pocket. The second one corresponds to residues that could form a kinase anion hole, with the conserved aspartate predicted to be the catalytic base [1]. We also developed a profile which covers the entire YjeF C-terminal domain.

Last update:

May 2008 / Text revised; profile added.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

YJEF_C_3, PS51383; YjeF C-terminal domain profile  (MATRIX)

YJEF_C_1, PS01049; YjeF C-terminal domain signature 1  (PATTERN)

YJEF_C_2, PS01050; YjeF C-terminal domain signature 2  (PATTERN)


1AuthorsZhang R.-G., Grembecka J., Vinokour E., Collart F., Dementieva I., Minor W., Joachimiak A.
TitleStructure of Bacillus subtilis YXKO--a member of the UPF0031 family and a putative kinase.
SourceJ. Struct. Biol. 139:161-170(2002).
PubMed ID12457846

2AuthorsZhou Y.-F., Li L.-F., Yang C., Liang Y.-H., Su X.-D.
TitlePreliminary X-ray crystallographic analysis of SMU.573, a putative sugar kinase from Streptococcus mutans.
SourceActa Crystallogr. F 64:47-49(2008).
PubMed ID18097102

3AuthorsAnantharaman V., Aravind L.
TitleNovel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability.
SourceBMC Genomics 5:45-45(2004).
PubMed ID15257761

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