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PROSITE documentation PDOC00810

SAICAR synthetase signatures

Description:

Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [1]. In bacteria (gene purC), fungi (gene ADE1) and plants, SAICAR synthetase is a monofunctional protein; in higher vertebrates it is the N-terminal domain of a bifunctional enzyme that also catalyze phosphoribosylaminoimidazole carboxylase (AIRC) activity.

As signature patterns for SAICAR synthetase, we selected two conserved regions in the central section of this enzyme.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE methods (with tools and information) covered by this documentation:

SAICAR_SYNTHETASE_1, PS01057; SAICAR synthetase signature 1  (PATTERN)
Consensus pattern: [LIVMRPA]-[LIVFY]-[PLNRKG]-[LIVMF]-E-x-[IV]-[LVCATI]-R-x(3)-[TAEYSI]-G-[ST]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01057
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01057
• Scan Swiss-Prot/TrEMBL entries against PS01057
• view ligand binding statistics
Matching PDB structures: 1A48 1OBD 1OBG 2CNQ ... [ALL]
SAICAR_SYNTHETASE_2, PS01058; SAICAR synthetase signature 2  (PATTERN)
Consensus pattern: [LI]-[IVCAP]-D-x-K-[LIFY]-E-[FI]-G
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01058
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01058
• Scan Swiss-Prot/TrEMBL entries against PS01058
• view ligand binding statistics
Matching PDB structures: 1A48 1OBD 1OBG 2CNQ ... [ALL]

Reference:

1 AuthorsZalkin H., Dixon J.E.
TitleDe novo purine nucleotide biosynthesis.
SourceProg. Nucleic Acid Res. Mol. Biol. 42:259-287(1992).
PubMed ID1574589

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