PROSITE documentation PDOC00820

Prokaryotic diacylglycerol kinase signature




Description

Diacylglycerol kinase (EC 2.7.1.107) (DAGK) is an enzyme that catalyzes the formation of phosphatidic acid from diacylglycerol and ATP, an important step in phospholipid biosynthesis. In bacteria DAGK is very small (13 to 15 Kd) membrane protein which seems to contain three transmembrane domains [1].

As a signature for bacterial DAGK, we selected the best conserved region, a stretch of 12 residues which are located in a cytoplasmic loop between the second and third transmembrane domains.

Last update:

July 1998 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

DAGK_PROKAR, PS01069; Prokaryotic diacylglycerol kinase signature  (PATTERN)


Reference

1AuthorsSmith R.L., O'Toole J.F., Maguire M.E., Sanders C.R. II
TitleMembrane topology of Escherichia coli diacylglycerol kinase.
SourceJ. Bacteriol. 176:5459-5465(1994).
PubMed ID8071224



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