|PROSITE documentation PDOC00820
Prokaryotic diacylglycerol kinase signature
Diacylglycerol kinase (EC 220.127.116.11) (DAGK) is an enzyme that catalyzes the
formation of phosphatidic acid from diacylglycerol and ATP, an important step
in phospholipid biosynthesis. In bacteria DAGK is very small (13 to 15 Kd)
membrane protein which seems to contain three transmembrane domains .
As a signature for bacterial DAGK, we selected the best conserved region, a
stretch of 12 residues which are located in a cytoplasmic loop between the
second and third transmembrane domains.
July 1998 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|DAGK_PROKAR, PS01069; Prokaryotic diacylglycerol kinase signature (PATTERN)
|Sequences known to belong to this class detected by the pattern:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
||Smith R.L., O'Toole J.F., Maguire M.E., Sanders C.R. II
||Membrane topology of Escherichia coli diacylglycerol kinase.
||J. Bacteriol. 176:5459-5465(1994).
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