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| PROSITE documentation PDOC00826 |
Acetate and butyrate kinases family signatures
Description:
The following enzymes have been shown [1,2] to be evolutionary related:
- Acetate kinase (EC 2.7.2.1) (acetokinase) (gene ackA) from bacteria and
archaebacteria. This enzyme is involved in the interconversion of acetate
and acetyl-CoA via the acetyl phosphate intermediate. In anaerobic growth
it provides ATP by catabolyzing acetate phosphate into acetate.
- Butyrate kinase (EC 2.7.2.7) (gene buk). This enzyme is involved in the
interconversion of butyrate and butyryl-CoA via the butyryl phosphate
intermediate. Butyrate kinase is involved in the acidogenic phase of
fermentation.
- Propionate kinase (EC 2.7.2,.) (gene tdcD) from Escherichia coli.
We have developed two signature patterns for these enzymes; the first one is
located in the N-terminal section and the second in the central section. Both
of them are glycine-rich and could be involved in substrate or ATP-binding.
Last update:
December 2004 / Pattern and text revised.
Technical section:
PROSITE methods (with tools and information) covered by this documentation:
| ACETATE_KINASE_1, PS01075; Acetate and butyrate kinases family signature 1 (PATTERN) |
| Consensus pattern: |
[LIVMFANT]-[LIVM]-x-[LIVMA]-N-x-G-S-[ST](2)-x-[KE]
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
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| Matching PDB structures:
1G99 1LP2 1LRG 1SAZ ... [ALL] |
| ACETATE_KINASE_2, PS01076; Acetate and butyrate kinases family signature 2 (PATTERN) |
| Consensus pattern: |
[LIVMFATQ]-[LIVMA]-x(2)-H-x-G-x-[GT]-x-[ST]-[LIVMA]-x-[TAVC]-x(3)-G
|
| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
|
|
|
| Matching PDB structures:
1G99 1LP2 1LRG 1SAZ ... [ALL] |
References:
| 1 |
Authors | Grundy F.J., Waters D.A., Allen S.H.G., Henkin T.M. |
| Title | Regulation of the Bacillus subtilis acetate kinase gene by CcpA. |
| Source | J. Bacteriol. 175:7348-7355(1993). |
| PubMed ID | 8226682 |
| 2 |
Authors | Oultram J.D., Burr I.D., Elmore M.J., Minton N.P. |
| Title | Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052. |
| Source | Gene 131:107-112(1993). |
| PubMed ID | 8396545 |
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