{PDOC00836}
{PS01137; TATD_1}
{PS01090; TATD_2}
{PS01091; TATD_3}
{BEGIN}
*********************************
* TatD deoxyribonuclease family *
*********************************

The Escherichia  coli  protein  tatD  is a cytoplasmic protein with magnesium-
dependent DNase  activity  [1].  It  is similar to a number of proteins in all
three kingdoms of life, among which:

 - Yeast chromosome II hypothetical protein YBL055c.
 - Escherichia  coli  hypothetical  protein ycfH and HI0454, the corresponding
   Haemophilus influenzae protein.
 - Escherichia  coli  hypothetical  protein yjjV and HI0081, the corresponding
   Haemophilus influenzae protein.
 - Bacillus subtilis hypothetical protein yabD.
 - Haemophilus influenzae hypothetical protein HI1664.
 - Mycoplasma genitalium hypothetical protein MG009.

These are  proteins  of  from  24 to 47 Kd which contain a number of conserved
regions. They can be picked up in the database by the following patterns.

-Consensus pattern: [LIVMFY](2)-D-[STA]-H-x-H-[LIVMFP]-[DN]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for yeast YBL055c and E.coli tatD.
-Other sequence(s) detected in Swiss-Prot: 4.

-Consensus pattern: P-[LIVM]-x-[LIVM]-H-x-R-x-[TA]-x-[DE]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for H.influenzae HI1664 and M.genitalium MG009.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [LVSAT]-[LIVA]-x(2)-[LIVMT]-[PSD]-x(3)-[LI]-[LIVMT]-
                    [LIVMST]-E-T-D-x-P
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Pattern and text revised.

[ 1] Wexler M., Sargent F., Jack R.L., Stanley N.R., Bogsch E.G.,
     Robinson C., Berks B.C., Palmer T.
     "TatD is a cytoplasmic protein with DNase activity. No requirement for
     TatD family proteins in sec-independent protein export."
     J. Biol. Chem. 275:16717-16722(2000).
     PubMed=10747959; DOI=10.1074/jbc.M000800200;

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}