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| PROSITE documentation PDOC00837 |
Adenylate cyclase class-I signatures
Description:
Adenylate cyclase (EC 4.6.1.1) is the enzyme responsible for the synthesis of
cAMP from ATP. From sequence data, it has been proposed [1,2] that there are
three different classes of adenylate cyclases. Class I cyclases are found in
enterobacteria and related Gram-negative bacteria. They are proteins of about
850 residues that consist of two functional domains: a N-terminal catalytic
domain and a C-terminal regulatory domain.
As signature patterns we selected two highly conserved regions, the first one
is located in the catalytic domain and the second one in the regulatory
domain. The second signature includes a conserved histidine which could be
phosphorylated by a PTS system IIA enzyme, thus leading to the activation of
the cyclase.
Expert(s) to contact by email:
Danchin A.
Last update:
November 1997 / Pattern and text revised.
Technical section:
PROSITE methods (with tools and information) covered by this documentation:
| ADENYLATE_CYCLASE_1_1, PS01092; Adenylate cyclase class-I signature 1 (PATTERN) |
| Consensus pattern: |
E-Y-F-G-[SA](2)-L-W-x-L-Y-K
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
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| ADENYLATE_CYCLASE_1_2, PS01093; Adenylate cyclase class-I signature 2 (PATTERN) |
| Consensus pattern: |
Y-R-N-x-W-[NS]-E-[LIVM]-R-T-L-H-F-x-G
H could be phosphorylated |
| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
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References:
| 1 |
Authors | Danchin A. |
| Title | Phylogeny of adenylyl cyclases. |
| Source | Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993). |
| PubMed ID | 8418825 |
| 2 |
Authors | Barzu O., Danchin A. |
| Title | Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes. |
| Source | Prog. Nucleic Acid Res. Mol. Biol. 49:241-283(1994). |
| PubMed ID | 7863008 |
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