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| PROSITE documentation PDOC00844 |
NNMT/PNMT/TEMT family of methyltransferases signature
Description:
The following cytoplasmic vertebrate methyltransferases are evolutionary
related [1,2]:
- Nicotinamide N-methyltransferase (EC 2.1.1.1) (NNMT). NNMT catalyzes the N-
methylation of nicotinamide and other pyridines to form pyridinium ions.
This activity is important for the biotransformation of many drugs and
xenobiotic compounds.
- Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMT). PNMT catalyzes
the last step in catecholamine biosynthesis, the conversion of noradrenalin
to adrenalin.
- Indolethylamine N-methyltransferase (EC 2.1.1.49) (INMT).
- Thioether S-methyltransferase (EC 2.1.1.96) (TEMT). TEMT catalyzes the
methylation of dimethyl sulfide into trimethylsulfonium.
These enzymes use S-adenosyl-L-methionine as the methyl donor. They are
proteins of 30 to 32 Kd. As a signature pattern we selected the most conserved
region, a stretch of 16 residues which are located in the N-terminal section
of these enzymes.
Last update:
December 2001 / Pattern and text revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| NNMT_PNMT_TEMT, PS01100; NNMT/PNMT/TEMT family of methyltransferases signature (PATTERN) |
| Consensus pattern: |
L-I-D-I-G-S-G-P-T-[IV]-Y-Q-[LV]-L-[SA]-A-C
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE |
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| Matching PDB structures:
1HNN 1N7I 1N7J 1YZ3 ... [ALL] |
References:
| 1 |
Authors | Aksoy S., Szumlanski C.L., Weinshilboum R.M. |
| Title | Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. |
| Source | J. Biol. Chem. 269:14835-14840(1994). |
| PubMed ID | 8182091 |
| 2 |
Authors | Thompson M.A., Moon E., Kim U.-J., Xu J., Siciliano M.J., Weinshilboum R.M. |
| Title | Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. |
| Source | Genomics 61:285-297(1999). |
| PubMed ID | 10552930 |
| DOI | 10.1006/geno.1999.5960 |
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