PROSITE documentation PDOC00867Elongation factor Ts signatures
In prokaryotes elongation factor Ts (EF-Ts) is a component of the elongation cycle of protein biosynthesis. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP, it remains bound to the aminoacyl-tRNA. EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome [1].
EF-Ts is also a component of the chloroplast protein biosynthetic machinery and is encoded in the genome of some algal chloroplast [2]. It is also present in mitochondria [3].
As signature patterns for EF-Ts, we selected two conserved regions located in the N-terminal part of the protein.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Bubunenko M.G. Kireeva M.L. Gudkov A.T. |
| Title | Novel data on interactions of elongation factor Ts. | |
| Source | Biochimie 74:419-425(1992). | |
| PubMed ID | 1637866 |
| 2 | Authors | Kostrzewa M. Zetsche K. |
| Title | Organization of plastid-encoded ATPase genes and flanking regions including homologues of infB and tsf in the thermophilic red alga Galdieria sulphuraria. | |
| Source | Plant Mol. Biol. 23:67-76(1993). | |
| PubMed ID | 8219057 |
| 3 | Authors | Xin H. Woriax V.L. Burkhart W. Spremulli L.L. |
| Title | Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver. | |
| Source | J. Biol. Chem. 270:17243-17249(1995). | |
| PubMed ID | 7615523 |
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