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	PROSITE documentation PDOC00911

The following methyltransferases have been shown [1] to share regions of similarities:

• Escherichia coli ubiE, which is involved in both ubiquinone and menaquinone biosynthesis and which catalyzes the S-adenosylmethionine dependent methylation of 2-polyprenyl-6-methoxy-1,4-benzoquinol into 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol and of demethylmenaquinol into menaquinol.
• Yeast COQ5, a ubiquinone biosynthesis methlytransferase.
• Bacillus subtilis spore germination protein C2 (gene: gercB or gerC2), a probable menaquinone biosynthesis methlytransferase.
• Lactococcus lactis gerC2 homolog.
• Caenorhabditis elegans hypothetical protein ZK652.9.
• Leishmania donovani amastigote-specific protein A41.

These are hydrophilic proteins of about 30 Kd (except for ZK652.9 which is 65 Kd). They can be picked up in the database by the following patterns.

Last update:

December 2004 / Patterns and text revised.

PROSITE methods (with tools and information) covered by this documentation:

UBIE_1, PS01183; ubiE/COQ5 methyltransferase family signature 1  (PATTERN)

• Consensus pattern:
  Y-[DN]-x-[MLAFTI]-N-x(2)-[LIVMN]-S-x(3)-[HQD]-x(2)-W
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 411
  • detected by PS01183: 399 (true positives)
  • undetected by PS01183: 12 (12 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01183:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01183
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01183
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01183
• View ligand binding statistics of PS01183
• Matching PDB structures: 4OBW 4OBX [ALL]

UBIE_2, PS01184; ubiE/COQ5 methyltransferase family signature 2  (PATTERN)

• Consensus pattern:
  R-V-[LIVMCT]-[KRQ]-[PVRK]-[GMKD]-[GAS]-x-[LIVMFAT]-x(2)-[LIVMCA]-[ED]-x-[SGT]
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 411
  • detected by PS01184: 354 (true positives)
  • undetected by PS01184: 57 (57 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01184:
  2 false positives.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01184
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01184
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01184
• View ligand binding statistics of PS01184
• Matching PDB structures: 4OBW 4OBX [ALL]

1	Authors	Lee P.T., Hsu A.Y., Ha H.T., Clarke C.F.
	Title	A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
	Source	J. Bacteriol. 179:1748-1754(1997).
	PubMed ID	9045837

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