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The following phosphorylases belongs to the same family:
Purine nucleoside phosphorylase (EC 188.8.131.52) (PNP) from most bacteria
(gene deoD). This enzyme catalyzes the cleavage of guanosine or inosine to
respective bases and sugar-1-phosphate molecules .
Uridine phosphorylase (EC 184.108.40.206) (UdRPase) from bacteria (gene udp) and
mammals. Catalyzes the cleavage of uridine into uracil and ribose-1-
phosphate. The products of the reaction are used either as carbon and
energy sources or in the rescue of pyrimidine bases for nucleotide
5'-methylthioadenosine phosphorylase (EC 220.127.116.11) (MTA phosphorylase) from
Sulfolobus solfataricus .
As a signature pattern, we selected a conserved region in the central part of
It should be noted that mammalian and some bacterial PNP as well as
eukaryotic MTA phosphorylase belong to a different family of phosphorylases
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
Takehara M., Ling F., Izawa S., Inoue Y., Kimura A.
Molecular cloning and nucleotide sequence of purine nucleoside phosphorylase and uridine phosphorylase genes from Klebsiella sp.
Cacciapuoti G., Porcelli M., Bertoldo C., De Rosa M., Zappia V.
Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosphorylase activity and evidence for intersubunit disulfide bonds.
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