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The following proteins are collectively termed cullins [1]:

• Caenorhabditis elegans cul-1 (or lin-19), a protein required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
• Caenorhabditis elegans cul-2, cul-3, cul-4 (F45E12.3), cul-5 (ZK856.1) and cul-6 (K08E7.7).
• Mammalian CUL1, CUL2, CUL3, CUL4A and CUL4B.
• Mammalian vasopressin-activated calcium-mobilizing receptor (VACM-1), a kidney-specific protein thought to form a cell surface receptor [2] but which does not have any structural hallmarks of a receptor.
• Drosophila lin19.
• Yeast CDC53 [3], which acts in concert with CDC4 and UBC3 (CDC34) to control the G1-to-S phase transition.
• Yeast hypothetical protein YGR003w.
• Fission yeast hypothetical protein SpAC24H6.03.

The cullins are hydrophilic proteins of 740 to 815 amino acids. The C-terminal extremity is the most conserved part of these proteins. We have developed a signature pattern from that region.

This documentation entry is linked to both a signature pattern and a profile. As the profile is much more sensitive than the pattern, you should use it if you have access to the necessary software tools to do so.

April 2006 / Pattern revised.

PROSITE methods (with tools and information) covered by this documentation:

CULLIN_2, PS50069; Cullin family profile  (MATRIX)

Sequences known to belong to this class detected by the profile: ALL Other sequence(s) detected in Swiss-Prot: 1.

• Domain architecture view of Swiss-Prot proteins matching PS50069 • Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS50069 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS50069 • Scan Swiss-Prot/TrEMBL entries against PS50069 • view ligand binding statistics

Matching PDB structures: 1LDJ 1LDK 1U6G 2HYE ... [ALL]

CULLIN_1, PS01256; Cullin family signature  (PATTERN)

Consensus pattern: [LIV]-[KL]-x(2)-[LIVM]-x(2)-L-[IL]-[DEQGVT]-[KRHNQ]-x-[YT]-[LIVM]-x-R-x(5,7)-[FYLV]-x-Y-x-[SAT] Sequences known to belong to this class detected by the pattern: ALL Other sequence(s) detected in Swiss-Prot: NONE.

• Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01256 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01256 • Scan Swiss-Prot/TrEMBL entries against PS01256 • view ligand binding statistics

Matching PDB structures: 1IUY 1LDJ 1LDK 1U6G ... [ALL]

1	Authors	Kipreos E.T., Lander L.E., Wing J.P., He W.W., Hedgecock E.M.
	Title	cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
	Source	Cell 85:829-839(1996).
	PubMed ID	8681378

2	Authors	Burnatowska-Hledin M.A., Spielman W.S., Smith W.L., Shi P., Meyer J.M., Dewitt D.L.
	Source	Am. J. Physiol. 268:f1198-F1210(1995).

3	Authors	Mathias N., Johnson S.L., Winey M., Adams A.E., Goetsch L., Pringle J.R., Byers B., Goebl M.G.
	Title	Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
	Source	Mol. Cell. Biol. 16:6634-6643(1996).
	PubMed ID	8943317

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