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	PROSITE documentation PDOC00991

The following eukaryotic proteins are evolutionary related and are thought to be involved in transcriptional regulation.

• Vertebrate protein TSC-22 [1]. This protein of 144 residues seems to act a transcriptional regulator on C-type natriuretic peptide (CNP) promoter.
• Mammalian protein DIP (DSIP-immunoreactive peptide) [2], a protein of 77 amino acids, whose function is not yet known.
• Drosophila protein bunched [3] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
• Caenorhabditis elegans hypothetical protein T18D3.7.

These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerization. As a signature pattern we selected a highly conserved stretch of residues that is located just in front of the leucine zipper.

Last update:

November 1997 / First entry.

PROSITE method (with tools and information) covered by this documentation:

TSC22, PS01289; TSC-22 / dip / bun family signature  (PATTERN)

• Consensus pattern:
  M-D-L-V-K-x-H-L-x(2)-A-V-R-E-E-V-E
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 20
  • detected by PS01289: 20 (true positives)
  • undetected by PS01289: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01289:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01289
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01289
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01289
• View ligand binding statistics of PS01289
• Matching PDB structures: 1DIP [ALL]

1	Authors	Ohta S., Shimekake Y., Nagata K.
	Title	Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.
	Source	Eur. J. Biochem. 242:460-466(1996).
	PubMed ID	9022669

2	Authors	Vogel P., Maegert H.J., Cieslak A., Adermann K., Forssmann W.-G.
	Title	hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues.
	Source	Biochim. Biophys. Acta 1309:200-204(1996).
	PubMed ID	8982256

3	Authors	Treisman J.E., Lai Z.C., Rubin G.M.
	Title	Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene.
	Source	Development 121:2835-2845(1995).
	PubMed ID	7555710

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