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	PROSITE documentation PDOC01008

The following proteins are evolutionary related:

• Escherichia coli ubiH, which is involved in ubiquinone biosynthesis and which catalyzes the convertion of 2-octaprenyl-6-methoxyphenol to 2- octaprenyl-6-methoxy-1,4-benzoquinone.
• Yeast COQ6, a ubiquinone biosynthesis monooxygenase.
• Caenorhabditis elegans hypothetical protein K07B1.2.
• Escherichia coli protein visC.
• Escherichia coli hypothetical protein yleB.
• Synechocystis strain PCC 6803 hypothetical protein slr1300.

UbiH and COQ6 are monooxygenases that requires FAD as a cofactor. These are proteins of 42 to 54 Kd that can be picked up by the following pattern.

Last update:

July 1998 / First entry.

PROSITE method (with tools and information) covered by this documentation:

UBIH, PS01304; ubiH/COQ6 monooxygenase family signature  (PATTERN)

• Consensus pattern:
  H-P-[LIV]-[AG]-G-Q-G-x-N-x-G-x(2)-D
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 15
  • detected by PS01304: 14 (true positives)
  • undetected by PS01304: 1 (1 false negative and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01304:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01304
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01304
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01304
• View ligand binding statistics of PS01304
• Matching PDB structures: 4K22 [ALL]

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