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| PROSITE documentation PDOC01019 |
Phosphatidate cytidylyltransferase signature
Description:
Phosphatidate cytidylyltransferase (EC 2.7.7.41) [1,2,3] (also known as CDP-diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of
CDP-diacylglycerol from CTP and phosphatidate (PA). CDP-diacylglycerol is an
important branch point intermediate in both prokaryotic and eukaryotic
organisms. CDS is a membrane-bound enzyme. As a signature pattern we selected
a conserved region located in the C-terminal part.
Last update:
December 2004 / Pattern and text revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| CDS, PS01315; Phosphatidate cytidylyltransferase signature (PATTERN) |
| Consensus pattern: |
S-x-[LIVMF]-K-R-x(4)-K-D-x-[GSA]-x(2)-[LIF]-[PGS]-x-H-G-G-[LIVMF]-x-D-R-[LIVMFT]-D
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE |
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References:
| 1 |
Authors | Sparrow C.P., Raetz C.R.H. |
| Title | Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli. |
| Source | J. Biol. Chem. 260:12084-12091(1985). |
| PubMed ID | 2995359 |
| 2 |
Authors | Shen H., Heacock P.N., Clancey C.J., Dowhan W. |
| Title | The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. |
| Source | J. Biol. Chem. 271:789-795(1996). |
| PubMed ID | 8557688 |
| 3 |
Authors | Saito S., Goto K., Tonosaki A., Kondo H. |
| Title | Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain. |
| Source | J. Biol. Chem. 272:9503-9509(1997). |
| PubMed ID | 9083091 |
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