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	PROSITE documentation PDOC01022

The following uncharacterized proteins have been shown [1] to be evolutionary related and to contain a tsaA-like domain:

• Escherichia coli hypothetical protein yaeB and HI0510, the corresponding Haemophilus influenzae protein.
• Agrobacterium tumefaciens Ti plasmid protein virR.
• Pseudomonas aeruginosa protein rcsF.
• Archaeoglobus fulgidus hypothetical protein AF0241.
• Archaeoglobus fulgidus hypothetical protein AF0433.
• Methanococcus jannaschii hypothetical protein MJ1583.
• Methanobacterium thermoautotrophicum hypothetical protein MTH1797.

These are proteins of from 120 to 240 amino-acid residues (with the exception of AF0433 which is 366 residues long). Although found predominantly in prokaryotes the tsaA-like domain is also found in plants, Drosophila and mammals (human, rat, mouse and others):

• Mammalian Nef-associated protein 1 (NAP1).

The structure of the tsaA-like domain contains a six-stranded anti-parallel β-barrel (see <PDB:2NV4>). The tsaA-like domain may bind S-adenosylmethionine (AdoMet) and possesses a methyltransferase activity [2].

As a signature pattern we selected a conserved region in the central part of the domain. We also developed a profile that covers the entire tsaA-like domain.

Last update:

February 2013 / Text revised; profile added.

PROSITE methods (with tools and information) covered by this documentation:

TSAA_2, PS51668; TsaA-like domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 17
  • detected by PS51668: 17 (true positives)
  • undetected by PS51668: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS51668:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS51668
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51668
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51668
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS51668
• View ligand binding statistics of PS51668
• Matching PDB structures: 1XQB 2NV4 3OKX [ALL]

TSAA_1, PS01318; TsaA-like domain signature  (PATTERN)

• Consensus pattern:
  G-[AV]-F-[STA]-x-R-[SA]-x(2)-R-P-N
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 17
  • detected by PS01318: 16 (true positives)
  • undetected by PS01318: 1 (1 false negative and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01318:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01318
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01318
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01318
• View ligand binding statistics of PS01318
• Matching PDB structures: 1XQB 2NV4 [ALL]

1	Authors	Bairoch A.
	Source	Unpublished observations (1998).

2	Authors	Forouhar F., Kuzin A., Seetharaman J., Lee I., Zhou W., Abashidze M., Chen Y., Yong W., Janjua H., Fang Y., Wang D., Cunningham K., Xiao R., Acton T.B., Pichersky E., Klessig D.F., Porter C.W., Montelione G.T., Tong L.
	Title	Functional insights from structural genomics.
	Source	J. Struct. Funct. Genomics 8:37-44(2007).
	PubMed ID	17588214
	DOI	10.1007/s10969-007-9018-3

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