|PROSITE documentation PDOC01025
Crossover junction endodeoxyribonuclease ruvC signature
RuvC (EC 184.108.40.206)  is a bacterial nuclease that resolves Holliday junction
intermediates in genetic recombination. It cleaves the cruciform structure in
supercoiled DNA by nicking to strands with the same polarity at sites
symmetrically opposed at the junction in the homologous arms and leaves a
5'terminal phosphate and a 3'terminal hydroxyl group.
It is a small protein of about 20 Kd. It requires and binds a magnesium ion.
As a signature pattern we selected a region located in the C-terminal part.
This region contains two aspartate residues implicated in the binding of the
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|RUVC, PS01321; Crossover junction endodeoxyribonuclease ruvC signature (PATTERN)
The 2 D's are magnesium ligands
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS01321:
||494 true positives with 51 false negatives.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01321:
|Matching PDB structures:
||Processing of recombination intermediates by the RuvABC proteins.
||Annu. Rev. Genet. 31:213-244(1997).
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