{PDOC01025}
{PS01321; RUVC}
{BEGIN}
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* Crossover junction endodeoxyribonuclease ruvC signature *
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RuvC (EC 3.1.22.4) [1] is a bacterial nuclease that resolves Holliday junction
intermediates in  genetic recombination. It cleaves the cruciform structure in
supercoiled DNA  by  nicking  to  strands  with  the  same  polarity  at sites
symmetrically opposed  at  the  junction  in  the homologous arms and leaves a
5'terminal phosphate and a 3'terminal hydroxyl group.

It is  a  small protein of about 20 Kd. It requires and binds a magnesium ion.
As a  signature  pattern  we selected a region located in the C-terminal part.
This region  contains  two aspartate residues implicated in the binding of the
magnesium ion.

-Consensus pattern: G-x-[GA]-x-[AG]-x-K-x-[EQA]-[IVM]-x(16,19)-D-x-[SAVT]-D-
                    [AG]-x-[AGS]-[LIVMCA]-[ACS]
                    [The 2 D's are magnesium ligands]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] West S.C.
     "Processing of recombination intermediates by the RuvABC proteins."
     Annu. Rev. Genet. 31:213-244(1997).
     PubMed=9442895; DOI=10.1146/annurev.genet.31.1.213

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