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PROSITE documentation PDOC01029

Diaminopimelate epimerase signature




Description

Diaminopimelate epimerase (EC 5.1.1.7) catalyzes the isomeriazation of L,L- to D,L-meso-diaminopimelate in the biosynthetic pathway leading from aspartate to lysine.

This enzyme is a protein of about 30 Kd. Two conserved cysteines seem [1] to function as the acid and base in the catalytic mechanism. As a signature pattern, we selected the region surrounding the first of these two active site cysteines.

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

DAP_EPIMERASE, PS01326; Diaminopimelate epimerase signature  (PATTERN)


Reference

1AuthorsCirilli M., Zheng R., Scapin G., Blanchard J.S.
TitleStructural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.
SourceBiochemistry 37:16452-16458(1998).
PubMed ID9843410
DOI10.1021/bi982138o



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