{PDOC01054}
{PS01356; HEMATOPO_REC_S_F2}
{BEGIN}
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* Short hematopoietin receptor family 2 signature *
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A number  of  receptors  for  lymphokines,  hematopoietic  growth  factors and
growth hormone-related  molecules  have  been  found to share a common binding
domain. These  receptors  are  designated as hematopoietin receptors [1,2] and
the corresponding ligands as hematopoietins. Further, hematopoietins have been
subdivided into  two  major  structural  groups:  Large/long  and  small/short
hematopoietins.

One subset  of  individual receptor chains that are part of receptor complexes
for small   hematopoietins   contain   common  structural  elements  in  their
extracellular parts:  an  immunoglobulin-like  domain at the N-terminal end of
the hematopoietin  receptor domain and a rather short cytoplasmic domain. They
define a structural subgroup containing the following chains:

 - Granulocyte/macrophage colony stimulating factor receptor alpha (GMCSFRA).
 - Interleukin-3 receptor alpha chain (IL3RA).
 - Interleukin-5 receptor alpha chain (IL5RA).
 - Interleukin-13 receptor alpha-1 chain (IL13RA1).
 - Interleukin-13 receptor alpha-2 chain (IL13RA2).

A schematic representation of the structure of these receptors is shown below:

 +-----------+-------------------------------------------xxxxxxx-------------+
 |  Ig-like  |  C C     C  C         Extracellular       XXXXXXX Cytoplasmic |
 +-----------+--|-|-----|--|-----------------------------xxxxxxx-------------+
                | |     |  |                          Transmembrane
                +-+     +--+

GMCSFRA, IL3RA  or  IL5RA  chains  of  this  subgroup  bind  to  their cognate
cytokines: GM-CSF, IL-3 and IL-5, with a common beta chain, KH97/AIC2B [3].

Either IL13RA1  chain  or  IL13RA2  chain form the IL13R complex together with
IL4RA chain. IL-4 can compete with IL-13 to bind to either IL13R form [4].

We have  used  one  pattern  to  detect this subfamily. The motif is located a
the N-terminal end of the 200 amino acid hematopoietin domain.

-Consensus pattern: [LIVM]-x-C-x-W-x(2)-G-x(5)-D-x(2)-Y-x-[LIVM]-x(10,14)-C
-Sequences known to belong to this class detected by the pattern: ALL
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Boulay J.-L.; Jean-Louis.Boulay@unibas.ch

-Last update: December 2001 / First entry.

[ 1] Boulay J.-L., Paul W.E.
     "Hematopoietin sub-family classification based on size, gene
     organization and sequence homology."
     Curr. Biol. 3:573-581(1993).
     PubMed=15335670
[ 2] Sprang S.R., Bazan J.F.
     Curr. Opin. Struct. Biol. 3:815-827(1993).
[ 3] Nicola N.A., Metcalf D.
     "Subunit promiscuity among hemopoietic growth factor receptors."
     Cell 67:1-4(1991).
     PubMed=1913811
[ 4] Hilton D.J., Zhang J.G., Metcalf D., Alexander W.S., Nicola N.A.,
     Willson T.A.
     "Cloning and characterization of a binding subunit of the interleukin
     13 receptor that is also a component of the interleukin 4 receptor."
     Proc. Natl. Acad. Sci. U.S.A. 93:497-501(1996).
     PubMed=8552669

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