|PROSITE documentation PDOC50133|
The FCH domain is a short conserved region of around 60 amino acids first described as a region of homology between FER and CIP4 proteins . Many proteins containing an FCH domain are involved in the regulation of cytoskeletal rearrangements, vesicular transport and endocytosis. In the CIP4 protein the FCH domain binds to microtubules . The FCH domain is always found N-terminally and is followed by a coiled-coil region.
Proteins containing an FCH domain can be divided in 3 classes :
A subfamily of protein kinases usually associated with an SH2 domain:
Adaptor proteins usually associated with a C-terminal SH3 domain:
A subfamily of Rho-GAP proteins:
The profile we developed covers the entire FCH domain.
August 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|FCH, PS50133; FCH domain profile (MATRIX)|
|Matching PDB structures: 2EFK 2EFL 2V0O 2X3V ... [ALL]|
|Title||A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton.|
|Source||Curr. Biol. 7:479-487(1997).|
|2||Authors||Tian L., Nelson D.L., Stewart D.M.|
|Title||Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules.|
|Source||J. Biol. Chem. 275:7854-7861(2000).|
|Title||Closing in on the biological functions of Fps/Fes and Fer.|
|Source||Nat. Rev. Mol. Cell Biol. 3:278-289(2002).|