{PDOC50244}
{PS50244; S5A_REDUCTASE}
{BEGIN}
*******************************************************
* Steroid 5-alpha reductase C-terminal domain profile *
*******************************************************

Steroid 5-alpha  reductases  (EC  1.3.99.5)  are  responsible  for  the NADPH-
dependent reduction  of  testosterone into dihydrotestosterone, a key reaction
in androgen action [1]. This enzyme  is  also  found  in  plants  where  it is
involved in    brassinosteroids  biosynthesis [2]. A domain of around 80 amino
acids is  found in the C-terminal part of the protein and contains the binding
site for NADPH [3].

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2002 / First entry.

[ 1] Russell D.W., Wilson J.D.
     "Steroid 5 alpha-reductase: two genes/two enzymes."
     Annu. Rev. Biochem. 63:25-61(1994).
     PubMed=7979239; DOI=10.1146/annurev.bi.63.070194.000325;
[ 2] Li J., Biswas M.G., Chao A., Russell D.W., Chory J.
     "Conservation of function between mammalian and plant steroid
     5alpha-reductases."
     Proc. Natl. Acad. Sci. U.S.A. 94:3554-3559(1997).
     PubMed=9108014
[ 3] Bhattacharyya A.K., Chavan A.J., Haley B.E., Taylor M.F., Collins D.C.
     "Identification of the NADP(H) binding site of rat liver microsomal 5
     alpha-reductase (isozyme-1): purification of a photolabeled peptide
     corresponding to the adenine binding domain."
     Biochemistry 34:3663-3669(1995).
     PubMed=7893662

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}