{PDOC50865}
{PS01360; ZF_MYND_1}
{PS50865; ZF_MYND_2}
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* Zinc finger MYND-type signature and profile *
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The  MYND-type  zinc  finger  was  called  after  the three best characterized
members  of  the  family  (MYeloid  translocation  protein 8 (MTG8/ETO), Nervy
protein and Deaf-1) [1]. In MTG8 and Bop proteins this domain is important for
the recruitment of a repressive complexe containing histone deacetylase (HDAC)
activity [2,3]. In M2-type chronic leukemia where AML1 is fused to MTG8, AML1,
normaly  a  transcriptional  activator,  is  converted  into a transcriptional
repressor.  The MYND domain of MTG8 is essential for this conversion and seems
to  function  by  recruiting  the  nuclear co-repressor N-CoR/mSin3A and HDACs
complexes to DNA sites specified by AML1 [2].

The  MYND-type  zinc  finger contains 8 amino acids that can coordinate 2 zinc
atoms.

Some proteins containing a MYND-type zinc finger are listed below:

 - Mammalian MTG8/ETO protein. MTG8 is part of a high molecular weight complex
   that contains co-repressors and HDACs.
 - Drosophila Nervy protein, a homologue of MTG8.
 - Animal  Deformed  epidermal  autoregulatory factor 1 (Deaf-1). It was first
   identified  in  drosophila  as a sequence-specific DNA binding protein that
   was isolated as a putative cofactor of the Hox protein Deformed (Dfd).
 - Vertebrate  Bop  protein.  In mouse it is expressed specifically in cardiac
   and  muscle  precursors  before  differentiation of these lineages.
 - Mammalian  programmed  cell  death protein 2 (PDCD2/RP8). It interacts with
   N-CoR/mSin3A  complexes  and with Host cell factor 1 (HCF1), a component of
   the C1 complex [4].
 - Adenovirus  5  E1A-binding  protein (BS69). It binds to the transactivation
   domain  of the adenovirus type 5 E1A 32 kda protein (289R) and inhibits its
   transactivating activity.

The profile and the pattern we developed cover the whole domain.

-Consensus pattern: [CH]-x(2,4)-C-x(7,17)-C-x(0,2)-C-x(4)-[YFT]-C-x(3)-[CH]-
                    x(6,9)-H-x(3,4)-C
-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: January 2003 / First entry.

[ 1] Gross C.T., McGinnis W.
     "DEAF-1, a novel protein that binds an essential region in a Deformed
     response element."
     EMBO J. 15:1961-1970(1996).
     PubMed=8617243
[ 2] Gelmetti V., Zhang J., Fanelli M., Minucci S., Pelicci P.G.,
     Lazar M.A.
     "Aberrant recruitment of the nuclear receptor corepressor-histone
     deacetylase complex by the acute myeloid leukemia fusion partner
     ETO."
     Mol. Cell. Biol. 18:7185-7191(1998).
     PubMed=9819405
[ 3] Gottlieb P.D., Pierce S.A., Sims R.J., Yamagishi H., Weihe E.K.,
     Harriss J.V., Maika S.D., Kuziel W.A., King H.L., Olson E.N.,
     Nakagawa O., Srivastava D.
     "Bop encodes a muscle-restricted protein containing MYND and SET
     domains and is essential for cardiac differentiation and
     morphogenesis."
     Nat. Genet. 31:25-32(2002).
     PubMed=11923873; DOI=10.1038/ng866
[ 4] Scarr R.B., Sharp P.A.
     "PDCD2 is a negative regulator of HCF-1 (C1)."
     Oncogene 21:5245-5254(2002).
     PubMed=12149646; DOI=10.1038/sj.onc.1205647

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