PROSITE documentation PDOC50903Rubredoxin-like domain profile
The rubredoxin-like domain is a 45- to 55-residue domain containing one iron atom tetrahedrally coordinated to four cysteinyl residues (Fe(S-Cys)4 center). It is involved in electron transfer processes [1,2].
The most conserved feature of the rubredoxin-like domain is the cluster of four cysteines involved in iron binding (Cys-x-x-Cys-x(n)-Cys-x-x-Cys) [2]. Structure analyses of several rubredoxin-like domains have shown that they are folded into a short three-stranded antiparallel β-sheet and a number of loops (see <PDB:1RDG>) [3,4,5,6].
Proteins known to contain a rubredoxin-like domain are listed below:
- Rubredoxin (Rd), a small electron-transfer prokaryotic protein (see <PDOC00179>).
- Rubrerythrin (Rr), a non-heme protein isolated from anaerobic sulfate- reducing bacteria.
- Flavorubredoxin, a bacterial protein involved in elctron transfer processes.
- Nigerythrin, a prokaryotic protein of unknown function.
The profile we developed covers the entire rubredoxin-like domain.
Last update:March 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | van Beeumen J.J. van Driessche G. Liu M.-Y. LeGall J. |
| Source | J. Biol. Chem. 266:20645-20653(1991). |
| 2 | Authors | Prickril B.C. Kurtz D.M. Jr. LeGall J. Voordouw G. |
| Title | Cloning and sequencing of the gene for rubrerythrin from Desulfovibrio vulgaris (Hildenborough). | |
| Source | Biochemistry 30:11118-11123(1991). | |
| PubMed ID | 1932032 |
| 3 | Authors | Frey M. Sieker L. Payan F. Haser R. Bruschi M. Pepe G. LeGall J. |
| Title | Rubredoxin from Desulfovibrio gigas. A molecular model of the oxidized form at 1.4 A resolution. | |
| Source | J. Mol. Biol. 197:525-541(1987). | |
| PubMed ID | 3441010 |
| 4 | Authors | Day M.W. Hsu B.T. Joshua-Tor L. Park J.-B. Zhou Z.H. Adams M.W.W. Rees D.C. |
| Title | X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus. | |
| Source | Protein Sci. 1:1494-1507(1992). | |
| PubMed ID | 1303768 |
| 5 | Authors | Sieker L.C. Stenkamp R.E. LeGall J. |
| Title | Rubredoxin in crystalline state. | |
| Source | Methods Enzymol. 243:203-216(1994). | |
| PubMed ID | 7830611 |
| 6 | Authors | deMare F. Kurtz D.M. Jr. Nordlund P. |
| Title | The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains. | |
| Source | Nat. Struct. Biol. 3:539-546(1996). | |
| PubMed ID | 8646540 |
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