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| PROSITE documentation PDOC50969 |
FCP1 homology domain profile
Description:
Yeast FCP1 is an essential protein serine phosphatase (EC 3.1.3.16) that
dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. FCP1
orthologs are present in all known eukaryote proteomes. The N-terminal domain
of FCP1 corresponds to the catalytic unit of the phosphatase and has been
refered to as the FCP1 homology domain. The FCP1 homology domain, which is a
~180-residue module, is also found in many other proteins of unknown function.
It contains a DxDx(T/V) motif preceded by four hydrophobic residues
characteristic of a large family of metal-dependant phosphohydrolases and
phosphotransferases. The first aspartate residue is likely to participate
in catalysis, whereas the second could have a role in substrate recognition
[1,2,3,4].
The profile we developed covers the entire FCP1 homology domain.
Last update:
March 2004 / First entry.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| FCP1, PS50969; FCP1 homology domain profile (MATRIX) |
| Sequences known to belong to this class detected by the profile: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE |
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| Matching PDB structures:
1T9Z 1TA0 2GHQ 2GHT ... [ALL] |
References:
| 1 |
Authors | Archambault J., Chambers R.S., Kobor M.S., Ho Y., Cartier M., Bolotin D., Andrews B., Kane C.M., Greenblatt J. |
| Title | An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae. |
| Source | Proc. Natl. Acad. Sci. U.S.A. 94:14300-14305(1997). |
| PubMed ID | 9405607 |
| 2 |
Authors | Kobor M.S., Archambault J., Lester W., Holstege F.C.P., Gileadi O., Jansma D.B., Jennings E.G., Kouyoumdjian F., Davidson A.R., Young R.A., Greenblatt J. |
| Title | An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae. |
| Source | Mol. Cell 4:55-62(1999). |
| PubMed ID | 10445027 |
| 3 |
Authors | Hausmann S., Shuman S. |
| Title | Defining the active site of Schizosaccharomyces pombe C-terminal domain phosphatase Fcp1. |
| Source | J. Biol. Chem. 278:13627-13632(2003). |
| PubMed ID | 12556522 |
| DOI | 10.1074/jbc.M213191200 |
| 4 |
Authors | Cho H., Kim T.-K., Mancebo H., Lane W.S., Flores O., Reinberg D. |
| Title | A protein phosphatase functions to recycle RNA polymerase II. |
| Source | Genes Dev. 13:1540-1552(1999). |
| PubMed ID | 10385623 |
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