{PDOC51029}
{PS51029; MADF}
{BEGIN}
***********************
* MADF domain profile *
***********************

The myb/SANT-like  domain  in  Adf-1  (MADF)  is  a ~80-amino-acid module that
directs sequence  specific  DNA  binding  to  a  site  consisting  of multiple
trinucleotide repeats.  The  MADF  domain  is  found  in one or more copies in
eukaryotic and  viral  proteins  and  is often associated with the BESS domain
(see <PDOC51031>) [1,2,3].

It is  likely  that  the  MADF  domain is more closely related to the myb/SANT
domain than it is to other HTH domains [1,2,3].

Some proteins known to contain a MADF domain are listed below:

 - Drosophila  Adf-1,  a transcription factor first identified on the basis of
   its interaction  with the alcohol dehydrogenase promoter but that binds the
   promoters of a diverse group of genes [1].
 - Drosophila  Dorsal-interacting  protein  3  (Dip3). It functions both as an
   activator to  bind  DNA  in  a  sequence  specific manner and a coactivator
   to stimulate synergistic activation by Dorsal and Twist [2].
 - Drosophila  Stonewall  (Stwl), a putative transcription factor required for
   maintenance of   female   germline   stem   cells   as   well   as   oocyte
   differentiation.

The profile we developed covers the entire MADF domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: October 2004 / First entry.

[ 1] England B.P., Admon A., Tjian R.
     "Cloning of Drosophila transcription factor Adf-1 reveals homology to
     Myb oncoproteins."
     Proc. Natl. Acad. Sci. U.S.A. 89:683-687(1992).
     PubMed=1731341
[ 2] Cutler G., Perry K.M., Tjian R.
     "Adf-1 is a nonmodular transcription factor that contains a
     TAF-binding Myb-like motif."
     Mol. Cell. Biol. 18:2252-2261(1998).
     PubMed=9528796
[ 3] Bhaskar V., Courey A.J.
     "The MADF-BESS domain factor Dip3 potentiates synergistic activation
     by Dorsal and Twist."
     Gene 299:173-184(2002).
     PubMed=12459265

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{END}