{PDOC51046} {PS51046; GON} {BEGIN} ********************** * GON domain profile * ********************** The ADAMTSs (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) are a family of zinc dependent metalloproteinases that play important roles in a variety of normal and pathological conditions. These enzymes show a complex domain organization including signal sequence, propeptide, metalloproteinase domain (see ), disintegrin-like domain (see ), central TS-1 motif (see ), cysteine-rich region, and a variable number of TS-like repeats at the C-terminal region. The GON domain is a ~200-residue module, whose presence is a hallmark of a subfamily of structurally and evolutionarily related ADAMTSs, called GON- ADAMTSs. The GON domain is characterized by the presence of several conserved cysteine residues and is likely to be globular [1,2]. Some proteins known to contain a GON domain are listed below: - Mammalian ADAMTS-9. - Mammalian ADAMTS-20. - Caenorhabditis elegans gon-1, a protease required for gonadal morphogenesis. The profile we developed covers the entire GON domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / First entry. [ 1] Llamazares M., Cal S., Quesada V., Lopez-Otin C. "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain." J. Biol. Chem. 278:13382-13389(2003). PubMed=12562771; DOI=10.1074/jbc.M211900200; [ 2] Somerville R.P.T., Longpre J.-M., Jungers K.A., Engle J.M., Ross M., Evanko S., Wight T.N., Leduc R., Apte S.S. "Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1." J. Biol. Chem. 278:9503-9513(2003). PubMed=12514189; DOI=10.1074/jbc.M211009200 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}