{PDOC51048}
{PS51048; SGS}
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* SGS domain profile *
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The SGT1-specific  (SGS)  domain  is  a  module  of ~90 amino acids, which was
initially identified in eukaryotic SGT1 proteins [1]. It was latter also found
in calcyclin-binding  proteins  [2].  The SGS domain has been shown to bind to
proteins of  the  S100  family,  which  are  thought to function as sensors of
calcium ion concentration in the cell [2].

Some proteins known to contain a SGS domain are listed below:

 - Yeast  suppressor  of the G2 allele of skp1 (SGT1). It is required for cell
   cycle progression   at   the  G1/S-phase  and  G2/M-phase  transitions.  It
   associates with  Skp1  and regulates its function in the Skp1/Cullin1/F-box
   complex ubiquitin ligase and in kinetochore complexes.
 - Arabidopsis thaliana SGT1a and SGT1b.
 - Mammalian SGT1.
 - Mammalian      calcyclin-binding     protein/Siah-1-interacting     protein
   (CacyBP/SIP), a    component   of   a   novel   pathway   of   beta-catenin
   ubiquitination.

The profile we developed covers the entire SGS domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / First entry.

[ 1] Azevedo C., Sadanandom A., Kitagawa K., Freialdenhoven A., Shirasu K.,
     Schulze-Lefert P.
     "The RAR1 interactor SGT1, an essential component of R gene-triggered
     disease resistance."
     Science 295:2073-2076(2002).
     PubMed=11847307; DOI=10.1126/science.1067554;
[ 2] Nowotny M., Spiechowicz M., Jastrzebska B., Filipek A., Kitagawa K.,
     Kuznicki J.
     "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and
     other S100 proteins."
     J. Biol. Chem. 278:26923-26928(2003).
     PubMed=12746458; DOI=10.1074/jbc.M211518200;

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