{PDOC51065}
{PS51065; NHR}
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* Neuralized homology repeat (NHR) domain profile *
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The neuralized  homology  repeat (NHR) domain is a module of ~160 amino acids,
which has  been  identified  as  a  tandem  repeat in drosophila neuralized, a
protein involved  in  development of the central and peripheral nervous system
[1]. Several  other  fly,  worm,  and  mammalian neuralized-like proteins were
found to  contain  between  one  and  six  NHR  domains  associated with other
modules, such  as  RING  (see  <PDOC00449>),  SOCS  (see <PDOC50225>), or SPRY
[2,3]. It  has  been  suggested  that  the  NHR  domain  is  required  for the
localization of neuralized to the plasma membrane [4]. As it has been proposed
that NHR  domains  do  partly  resemble  SPRY domains, it is possible that NHR
possess microtubule-binding  functions,  similar  to  those  proposed for SPRY
domains [3].

Some proteins known to contain a NHR domain are listed below:

 - Drosophila neuralized protein. It is involved in neurogenesis and interacts
   with other  neurogenic  proteins  in  the  specification  of the neuroblast
   versus epidermoblast cell fate.
 - Mammalian  neuralized-like  protein  2.  It  plays an important role in the
   process of myofiber differentiation and maturation.

The profile we developed covers the entire NHR domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Note: The NHR domain has also been called NEUZ domain [2,3].

-Last update: January 2005 / First entry.

[ 1] Nakamura H., Yoshida M., Tsuiki H., Ito K., Ueno M., Nakao M., Oka K.,
     Tada M., Kochi M., Kuratsu J., Ushio Y., Saya H.
     "Identification of a human homolog of the Drosophila neuralized gene
     within the 10q25.1 malignant astrocytoma deletion region."
     Oncogene 16:1009-1019(1998).
     PubMed=9519875; DOI=10.1038/sj.onc.1201618
[ 2] Doerks T., Copley R.R., Schultz J., Ponting C.P., Bork P.
     "Systematic identification of novel protein domain families associated
     with nuclear functions."
     Genome Res. 12:47-56(2002).
     PubMed=11779830
[ 3] Ponting C.P., Mott R., Bork P., Copley R.R.
     "Novel protein domains and repeats in Drosophila melanogaster:
     insights into structure, function, and evolution."
     Genome Res. 11:1996-2008(2001).
     PubMed=11731489; DOI=10.1101/gr.198701
[ 4] Yeh E., Dermer M., Commisso C., Zhou L., McGlade C.J., Boulianne G.L.
     "Neuralized functions as an E3 ubiquitin ligase during Drosophila
     development."
     Curr. Biol. 11:1675-1679(2001).
     PubMed=11696324

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