{PDOC51079}
{PS51079; MBT}
{BEGIN}
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* MBT repeat profile *
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The  Polycomb-group  protein Sex Comb on midleg (SCM) and the tumor suppressor
protein  lethal  (3) malignant brain tumor (l(3)mbt) , share a homology region
consisting  of  two repeats, each about 100 amino acids in length. This repeat
has been name MBT after its occurence in l(3)mbt [1].

The  structure  of  MBT  repeats  has been solved (see <PDB:1OI1>) [2,3]. Each
repeat consists of an extended "arm" and a globular core. The arm of the first
repeat  packs  against  the core of the second repeat and vice versa. The core
consists  of  an  SH3-like  five stranded beta-barrel followed by a C-terminal
alpha-helice   and   another   short  beta-strand.  The  MBT  structure  shows
significant  similarities  with  the  Tudor  (see  <PDOC50304>), the PWWP (see
<PDOC50812>)  and  the chromo (see <PDOC00517>) domains within the beta-barrel
portion  of  the structure. Given their similarity to these domains, a binding
role   is  probable,  and  post-translationally  modified  histones  are  good
candidates for binding targets [3,4].

The profile we developed covers the whole MBT repeat.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: February 2005 / First entry.

[ 1] Bornemann D., Miller E., Simon J.
     "The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a
     zinc finger protein with similarity to polyhomeotic protein."
     Development 122:1621-1630(1996).
     PubMed=8625848
[ 2] Wang W.K., Tereshko V., Boccuni P., MacGrogan D., Nimer S.D.,
     Patel D.J.
     "Malignant brain tumor repeats: a three-leaved propeller architecture
     with ligand/peptide binding pockets."
     Structure 11:775-789(2003).
     PubMed=12842041
[ 3] Sathyamurthy A., Allen M.D., Murzin A.G., Bycroft M.
     "Crystal structure of the malignant brain tumor (MBT) repeats in Sex
     Comb on Midleg-like 2 (SCML2)."
     J. Biol. Chem. 278:46968-46973(2003).
     PubMed=12952983; DOI=10.1074/jbc.M306469200
[ 4] Maurer-Stroh S., Dickens N.J., Hughes-Davies L., Kouzarides T.,
     Eisenhaber F., Ponting C.P.
     Trends Biochem. Sci. 28:69-74(2003).

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