{PDOC51083}
{PS51083; ZF_HIT}
{BEGIN}
********************************
* Zinc finger HIT-type profile *
********************************

The HIT-type zinc finger contains 7 conserved cysteines and one histidine that
can  potentially  coordinate two zinc atoms. It has been named after the first
protein  that  originally  defined the domain: the yeast HIT1 protein [1]. The
HIT-type zinc finger displays some sequence similarities to the MYND-type zinc
finger  (see  <PDOC50865>).  The  function of this domain is unknown but it is
mainly  found  in  nuclear  proteins involved in gene regulation and chromatin
remodeling.

Some proteins known to contain a HIT-type zinc finger are listed below:

 - Mammalian  thyroid hormone receptors interacting protein 3 (Trip3). It also
   interacts  with  the  retinoid X receptor and activates the transcriptional
   factor HNF-4alpha [2].
 - Mammalian FON protein.
 - Yeast HIT1 protein. It is required for high temperature growth.
 - Yeast VPS71 protein. It is a component  of the chromatin remodeling complex
   Swr1,  which catalyzes the exchange of histone H2A to histone variant H2AZ.
   This step has an important influence on gene expression [3].

The profile we developed covers the whole HIT-type zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: February 2005 / First entry.

[ 1] Kawakami K., Shafer B.K., Garfinkel D.J., Strathern J.N., Nakamura Y.
     "Ty element-induced temperature-sensitive mutations of Saccharomyces
     cerevisiae."
     Genetics 131:821-832(1992).
     PubMed=1325386
[ 2] Iwahashi H., Yamagata K., Yoshiuchi I., Terasaki J., Yang Q.,
     Fukui K., Ihara A., Zhu Q., Asakura T., Cao Y., Imagawa A., Namba M.,
     Hanafusa T., Miyagawa J., Matsuzawa Y.
     "Thyroid hormone receptor interacting protein 3 (trip3) is a novel
     coactivator of hepatocyte nuclear factor-4alpha."
     Diabetes 51:910-914(2002).
     PubMed=11916906
[ 3] Mizuguchi G., Shen X., Landry J., Wu W.H., Sen S., Wu C.
     "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1
     chromatin remodeling complex."
     Science 303:343-348(2004).
     PubMed=14645854; DOI=10.1126/science.1090701

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}