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	PROSITE documentation PDOC51137

In Drosophila melanogaster the vitelline membrane (VM) is the first layer of the eggshell produced by the follicular epithelium. It is composed of at least four different proteins. VM proteins are similarly organized with a central highly conserved 38-amino acid domain which is flanked by unrelated regions. Since the surrounding regions have diverged significantly, it is possible that the VM domain is of key importance in VM protein structure [1,2].

The profile we developed covers the entire VM domain.

Last update:

June 2005 / First entry.

PROSITE method (with tools and information) covered by this documentation:

VM, PS51137; VM domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 17
  • detected by PS51137: 14 (true positives)
  • undetected by PS51137: 3 (3 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS51137:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS51137
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51137
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51137
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS51137
• View ligand binding statistics of PS51137

1	Authors	Scherer L.J., Harris D.H., Petri W.H.
	Title	Drosophila vitelline membrane genes contain a 114 base pair region of highly conserved coding sequence.
	Source	Dev. Biol. 130:786-788(1988).
	PubMed ID	3143615

2	Authors	Scherer L.J., Harris D.H., White M.K., Steel L.F., Jin J., Petri W.H.
	Title	Comparative analysis of the sequence and structure of two Drosophila melanogaster genes encoding vitelline membrane proteins.
	Source	Gene 136:121-127(1993).
	PubMed ID	8293994

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