{PDOC51215} {PS51215; AWS} {BEGIN} ********************** * AWS domain profile * ********************** The SET domain is an evolutionarily conserved domain found predominantly in histone methyltransferases (HMTs) (see ). Not all SET domain- containing proteins possess HMTase activities. The HTMase activity is probably restricted to a subset of SET domain proteins as it requires the combination of the SET domain with the adjacent cysteine-rich regions, one located N- terminally (pre-SET) and the other posterior to the SET domain (post-SET). In a subset of SET and post-SET containing proteins, a so-called associated with SET (AWS) domain is found instead of the pre-SET domain. In addition to the SET and post-SET domains to which it is always associated, the AWS domain can also be found with PWWP (see ), AT-hook, WW (see ), PHD (see ) or BAH (see ) [1-3]. Some proteins known to contain an AWS domain are listed below: - Yeast set-2 protein. - Human huntingtin-interacting protein B (HYPB). The profile we developed covers the entire AWS domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: June 2006 / First entry. [ 1] Doerks T., Copley R.R., Schultz J., Ponting C.P., Bork P. "Systematic identification of novel protein domain families associated with nuclear functions." Genome Res. 12:47-56(2002). PubMed=11779830; DOI=10.1101/ [ 2] Adhvaryu K.K., Morris S.A., Strahl B.D., Selker E.U. "Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa." Eukaryot. Cell 4:1455-1464(2005). PubMed=16087750; DOI=10.1128/EC.4.8.1455-1464.2005 [ 3] Sun X.-J., Wei J., Wu X.-Y., Hu M., Wang L., Wang H.-H., Zhang Q.-H., Chen S.-J., Huang Q.-H., Chen Z. "Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase." J. Biol. Chem. 280:35261-35271(2005). PubMed=16118227; DOI=10.1074/jbc.M504012200 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}