PROSITE documentation PDOC51220NIDO domain profile
Description
The ~180-residue NIDO domain is an extracellular domain of unknown function, found in nidogen (entactin) and hypothetical proteins. The NIDO domain is found in association with other domains, such as nidogen G2 β-barrel (see <PDOC50993>), thyroglobulin type-1 (see <PDOC00377>), LDLRB (see <PDOC51120>), AMOP (see <PDOC50856>), EGF-like (see <PDOC00021>), VWFD, IPT/TIG, or sushi/CCP/SCR (see <PDOC50923>) [1,2,3,4].
Some proteins known to contain a NIDO domain are listed below:
- Vertebrate nidogen-1 (NID-1) or entactin, a sulfated glycoprotein widely distributed in basement membranes.
- Vertebrate nidogen-2 (NID-2) or osteonidogen, a cell adhesion glycoprotein which is widely distributed in basement membranes.
- Vertebrate α-tectorin.
- Mammalian mucin-4 (MUC4), a highly glycosylated membrane-bound protein.
- Xenopus ID14, a putative matrix protein.
The profile we developed covers the entire NIDO domain.
Last update:June 2006 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Ciccarelli F.D. Doerks T. Bork P. |
| Title | AMOP, a protein module alternatively spliced in cancer cells. | |
| Source | Trends Biochem. Sci. 27:113-115(2002). | |
| PubMed ID | 11893501 |
| 2 | Authors | Desseyn J.-L. Clavereau I. Laine A. |
| Title | Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4. | |
| Source | Eur. J. Biochem. 269:3150-3159(2002). | |
| PubMed ID | 12084055 |
| 3 | Authors | Buchholz D.R. Ishizuya-Oka A. Shi Y.-B. |
| Title | Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis. | |
| Source | Gene Expr. Patterns 4:321-328(2004). | |
| PubMed ID | 15053982 | |
| DOI | 10.1016/j.modgep.2003.10.005 |
| 4 | Authors | Duraisamy S. Ramasamy S. Kharbanda S. Kufe D. |
| Title | Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16. | |
| Source | Gene 373:28-34(2006). | |
| PubMed ID | 16500040 | |
| DOI | 10.1016/j.gene.2005.12.021 |
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