{PDOC51279}
{PS51279; BCNT_C}
{BEGIN}
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* Bucentaur C-terminal (BCNT-C) domain profile *
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Vertebrate BCNT  (named  after  Bucentaur) protein is found in the nucleus and
cytosol. Gene  duplication of the ancestral BCNT gene leads to the h-type BCNT
or craniofacial  development  protein 1 (CFDP1) gene and the ruminant-specific
p97BCNT or  craniofacial  development  protein 2 (CFDP2) gene. The h-type BCNT
proteins contain  a  highly  conserved  82-amino acid region at the C-terminus
(BCNT-C) that  is  not present in p97BCNT. Instead ruminant p97BCNT contains a
region derived  from  the  endonuclease  domain of a retrotransposable element
RTE-1 [1,2].  In  addition  to  h-type  BCNT proteins, a BCNT-C domain is also
found in  Drosophila  YETI,  a protein that binds to a microtubule-based motor
kinesin-1, and  the  yeast  SWR1-complex  protein  5  (SWC5)  or  AOR1  (actin
overexpression resistant  1),  a  component  of  the SWR1 chromatin remodeling
complex [2,3].

The profile we developed covers the entire BCNT-C domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2006 / First entry.

[ 1] Iwashita S., Osada N., Itoh T., Sezaki M., Oshima K., Hashimoto E.,
     Kitagawa-Arita Y., Takahashi I., Masui T., Hashimoto K.,
     Makalowski W.
     "A transposable element-mediated gene divergence that directly
     produces a novel type bovine Bcnt protein including the endonuclease
     domain of RTE-1."
     Mol. Biol. Evol. 20:1556-1563(2003).
     PubMed=12832649; DOI=10.1093/molbev/msg168
[ 2] Iwashita S., Ueno S., Nakashima K., Song S.-Y., Ohshima K., Tanaka K.,
     Endo H., Kimura J., Kurohmaru M., Fukuta K., David L., Osada N.
     "A tandem gene duplication followed by recruitment of a
     retrotransposon created the paralogous bucentaur gene (bcntp97) in the
     ancestral ruminant."
     Mol. Biol. Evol. 23:798-806(2006).
     PubMed=16384818; DOI=10.1093/molbev/msj088
[ 3] Wisniewski T.P., Tanzi C.L., Gindhart J.G.
     "The Drosophila kinesin-I associated protein YETI binds both kinesin
     subunits."
     Biol. Cell 95:595-602(2003).
     PubMed=14720462

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