{PDOC51302}
{PS51302; SIM_C}
{BEGIN}
*****"*************************************
* Single-minded C-terminal domain profile *
*******************************************

In Drosophila,  single-minded (sim) is a transcription factor that acts as the
master regulator  of  neurogenesis.  Two  mammalian  homologs of Sim, Sim1 and
Sim2, have  been identified. There is a high level of homology among mammalian
and Drosophila  sim  proteins in their amino-terminal half where the conserved
bHLH (see  <PDOC00038>), PAS (see <PDOC50112>) and HST domains are present. In
contrast, the  carboxy-terminal  parts  are only conserved in vertebrates [1].
The Sim1  C-terminus  contains  a Ser-rich region, whereas the Sim2 C-terminus
both contain Ser/Thr-rich regions, Pro/Ser-rich regions, Pro/Ala-rich regions,
and positively  charged  regions.  Sim2s,  a  splice  variant  of  Sim2, still
contains the  Ser/Thr-  and  Pro/Ser-rich  regions  shown to harbor repressive
activities, but is missing the Pro/Ala-rich repressor region [1-3].

The profile we developed covers the entire single-minded C-terminal domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2007 / First entry.

[ 1] Chrast R., Scott H.S., Chen H., Kudoh J., Rossier C., Minoshima S.,
     Wang Y., Shimizu N., Antonarakis S.E.
     "Cloning of two human homologs of the Drosophila single-minded gene
     SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome
     chromosomal region."
     Genome Res. 7:615-624(1997).
     PubMed=9199934
[ 2] Coumailleau P., Penrad-Mobayed M., Lecomte C., Bollerot K., Simon F.,
     Poellinger L., Angelier N.
     "Characterization and developmental expression of xSim, a Xenopus
     bHLH/PAS gene related to the Drosophila neurogenic master gene
     single-minded."
     Mech. Dev. 99:163-166(2000).
     PubMed=11091086
[ 3] Metz R.P., Kwak H.-I., Gustafson T., Laffin B., Porter W.W.
     "Differential transcriptional regulation by mouse single-minded 2s."
     J. Biol. Chem. 281:10839-10848(2006).
     PubMed=16484282; DOI=10.1074/jbc.M508858200

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