PROSITE documentation PDOC51325Alpha box DNA-binding domain profile
Sexual reproduction in ascomycetes is controlled by a single regulatory locus, referred to as a mating type type (MAT). The single MAT locus has alternate forms, termed idiomorphs, that must be different for two isolates to mate. All ascomycete MAT idiomorphs encode proteins with confirmed or putative DNA-binding motifs, such as an α box for MAT1-1 strains and a high mobility group (HMG) (see <PDOC00305>) DNA-binding domain for MAT1-2 strains [1,2]. The α box domain is related to the HMG domain [3].
The profile we developed covers the entire α box DNA-binding domain.
Last update:February 2011 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Arie T. Kaneko I. Yoshida T. Noguchi M. Nomura Y. Yamaguchi I. |
| Title | Mating-type genes from asexual phytopathogenic ascomycetes Fusarium oxysporum and Alternaria alternata. | |
| Source | Mol. Plant Microbe Interact. 13:1330-1339(2000). | |
| PubMed ID | 11106025 |
| 2 | Authors | Cozijnsen A.J. Howlett B.J. |
| Title | Characterisation of the mating-type locus of the plant pathogenic ascomycete Leptosphaeria maculans. | |
| Source | Curr. Genet. 43:351-357(2003). | |
| PubMed ID | 12679880 | |
| DOI | 10.1007/s00294-003-0391-6 |
| 3 | Authors | Martin T. Lu S.-W. van Tilbeurgh H. Ripoll D.R. Dixelius C. Turgeon B.G. Debuchy R. |
| Title | Tracing the origin of the fungal alpha1 domain places its ancestor in the HMG-box superfamily: implication for fungal mating-type evolution. | |
| Source | PLoS ONE 5:E15199-E15199(2010). | |
| PubMed ID | 21170349 | |
| DOI | 10.1371/journal.pone.0015199 |
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