{PDOC51358}
{PS51358; NOP}
{BEGIN}
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* Nop domain profile *
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The ~120-residue   Nop   domain  is  present  in  various  pre-RNA  processing
ribonucleoproteins (RNP):

 - Eukaryotic  Prp31,  part of a tri-snRNP complex. It is involved in pre-mRNA
   splicing.
 - Eukaryotic  Nucleolar  proteins  56 and 58 (Nop56 and Nop58), components of
   box C/D small nucleolar ribonucleoprotein (snoRNP) particles.
 - Archaeal Nop5, an homolog of Nop56/Nop58.

The Nop  domain  is  a  RNP binding module, exhibiting RNA and protein binding
surfaces. It  is  oval-shaped  and  exclusively alpha-helical (see <PDB:2OZB>)
[1,2].

The profile we developed covers the entire Nop domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2012 / First entry.

[ 1] Aittaleb M., Rashid R., Chen Q., Palmer J.R., Daniels C.J., Li H.
     "Structure and function of archaeal box C/D sRNP core proteins."
     Nat. Struct. Biol. 10:256-263(2003).
     PubMed=12598892; DOI=10.1038/nsb905
[ 2] Liu S., Li P., Dybkov O., Nottrott S., Hartmuth K., Luehrmann R.,
     Carlomagno T., Wahl M.C.
     "Binding of the human Prp31 Nop domain to a composite RNA-protein
     platform in U4 snRNP."
     Science 316:115-120(2007).
     PubMed=17412961; DOI=10.1126/science.1137924

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