{PDOC51482} {PS51482; DEGV} {BEGIN} *********************** * DegV domain profile * *********************** The DegV protein family received its name based on sequence similarity to the DegV protein from Bacillus subtilis. All members of the DegV family are from bacteria, mostly Firmicutes. The function of DegV proteins is not yet completely understood, but structural evidence indicates that they can bind different fatty acids [1,2]. The DegV domain consists of two different alpha/beta folds (see ). The N-terminal domain, which contains seven beta-strands and six alpha- helices, can be further divided into two subdomains: a three-layer alpha/beta core domain and a small peripheral subdomain including a three-stranded antiparallel beta-sheet and one alpha-helix. The C-terminal domain contains six beta-strands and five alpha-helices in a two-layered alpha/beta- arrangement. The two domains mainly interact through hydrophobic contacts and form a ligand-binding pocket at the domain interface [1,2]. The profile we developed covers the entire DegV domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: February 2010 / First entry. [ 1] Schulze-Gahmen U., Pelaschier J., Yokota H., Kim R., Kim S.-H. "Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein." Proteins 50:526-530(2003). PubMed=12577257; DOI=10.1002/prot.10305 [ 2] Nan J., Zhou Y., Yang C., Brostromer E., Kristensen O., Su X.-D. "Structure of a fatty-acid-binding protein from Bacillus subtilis determined by sulfur-SAD phasing using in-house chromium radiation." Acta Crystallogr. D 65:440-448(2009). PubMed=19390149; DOI=10.1107/S0907444909007756 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}