{PDOC51633}
{PS51633; CXC}
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* CXC domain profile *
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Polycomb group  (Pc-G)  proteins  ensure  the stable inheritance of expression
patterns through cell division and regulate the control of cell proliferation.
The Enhancer of zeste (E(z))-type of Pc-G proteins includes:

 - Drosophila melanogaster Enhancer of zeste E(z).
 - Mammalian ENX-1 and ENX-2.
 - Arabidopsis  thaliana  CURLY  LEAF  (CLF),  a  transcriptional repressor of
   floral homeotic gene AGAMOUS.
 - Arabidopsis thaliana CLF-like.
 - Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.
 - Arabidopsis thaliana EZA1.

These proteins  contain  a  SET  domain  (see  <PDOC50280>) at the C-terminus.
Unique to them is the presence of a CXC domain, an ~65-residue cys-rich region
preceding the  SET  domain.  The  spacing of 17 cyteines is conserved. The CXC
domain contains three units of C-X(6)-C-X(3)-C-X-C motif, although the most C-
terminal unit  is  reverse-oriented. Because of its evolutionary conservation,
the CXC  domain  is  likely  to  be involved in an important function of E(z)-
related proteins [1,2,3].

The CXC  domain  shows  some similarity to the CRC domain found in the tesmin/
TSO1 protein family (see <PDOC51634>) [4].

The profile we developed covers the entire CXC domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2012 / First entry.

[ 1] Hobert O., Sures I., Ciossek T., Fuchs M., Ullrich A.
     "Isolation and developmental expression analysis of Enx-1, a novel
     mouse Polycomb group gene."
     Mech. Dev. 55:171-184(1996).
     PubMed=8861097
[ 2] Hobert O., Jallal B., Ullrich A.
     "Interaction of Vav with ENX-1, a putative transcriptional regulator
     of homeobox gene expression."
     Mol. Cell. Biol. 16:3066-3073(1996).
     PubMed=8649418
[ 3] Ogawa M., Hiraoka Y., Taniguchi K., Aiso S.
     "Cloning and expression of a human/mouse Polycomb group gene,
     ENX-2/Enx-2."
     Biochim. Biophys. Acta 1395:151-158(1998).
     PubMed=9473645
[ 4] Andersen S.U., Algreen-Petersen R.G., Hoedl M., Jurkiewicz A.,
     Cvitanich C., Braunschweig U., Schauser L., Oh S.-A., Twell D.,
     Jensen E.O.
     "The conserved cysteine-rich domain of a tesmin/TSO1-like protein
     binds zinc in vitro and TSO1 is required for both male and female
     fertility in Arabidopsis thaliana."
     J. Exp. Bot. 58:3657-3670(2007).
     PubMed=18057042; DOI=10.1093/jxb/erm215

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