{PDOC51664}
{PS51664; YCAO}
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* YcaO domain profile *
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The YcaO domain is found in the following proteins:

 - Escherichia  YcaO,  involved  in beta-methylthiolation of ribosomal protein
   S12 [1].
 - Bacterial  and archeal thiazole/oxazole-modified microcin (TOMM) D protein,
   which uses ATP to activate amide backbones during peptide cyclodehydrations
   [2].

The YcaO  domain  is  likely to be involved in post-translational modification
(PTM) of amino acid residues.

The profile we developed covers the entire YcaO domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2013 / First entry.

[ 1] Strader M.B., Costantino N., Elkins C.A., Chen C.Y., Patel I.,
     Makusky A.J., Choy J.S., Court D.L., Markey S.P., Kowalak J.A.
     "A proteomic and transcriptomic approach reveals new insight into
     beta-methylthiolation of Escherichia coli ribosomal protein S12."
     Mol. Cell. Proteomics 10:M110.005199-M110.005199(2011).
     PubMed=21169565; DOI=10.1074/mcp.M110.005199
[ 2] Dunbar K.L., Melby J.O., Mitchell D.A.
     "YcaO domains use ATP to activate amide backbones during peptide
     cyclodehydrations."
     Nat. Chem. Biol. 8:569-575(2012).
     PubMed=22522320; DOI=10.1038/nchembio.944

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