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	PROSITE documentation PDOC51667

The plant GROWTH-REGULATING FACTOR (GRF) proteins are putative transcription factors. They contain one or two WRC (Trp, Arg, Cys) domain(s). The WRC domain has two distinctive structural features, namely many basic amino acids (Arg and Lys) and the conserved spacing of three Cys and one His residues, the C3H motif. The basic amino acids are highly conserved, indicating that they are essential for the function of the WRC domain, probably as nuclear localization signal. The C3H motif is also absolutely conserved and may mediate binding to DNA [1].

The profile we developed covers the entire WRC domain.

Last update:

May 2013 / Text revised.

PROSITE method (with tools and information) covered by this documentation:

WRC, PS51667; WRC domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 22
  • detected by PS51667: 22 (true positives)
  • undetected by PS51667: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS51667:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS51667
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51667
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51667
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS51667
• View ligand binding statistics of PS51667

1	Authors	Kim J.H., Choi D., Kende H.
	Title	The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis.
	Source	Plant J. 36:94-104(2003).
	PubMed ID	12974814

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