{PDOC51671}
{PS51671; ACT}
{PS51672; ACT_LIKE}
{BEGIN}
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* ACT and ACT-like domain profiles *
************************************

The ACT  domain  is  a  90  amino acid long domain, which has been named after
three of  the allosterically regulated enzymes in which it is found: aspartate
kinase, chorismate  mutase  and  TyrA  (prephenate dehydrogenase) [1]. The ACT
domain is  found in a variety of contexts and is proposed to be a structurally
conserved regulatory  domain involved in the binding of small ligands, such as
amino acids.  Most  of the proteins in which it is found are involved in amino
acid and purine metabolism:

 - aspartokinases,
 - chorismate mutases,
 - prephenate dehydrogenases (TyrA),
 - prephenate dehydratases,
 - homoserine dehydrogenases,
 - malate dehydrogenases,
 - phosphoglycerate dehydrogenases,
 - phenylalanine and tryptophan-4-monooxygenases,
 - phosphoribosylformylglycinamidine synthase (PurQ),
 - uridylyl transferase and removing enzyme (GlnD),
 - GTP pyrophosphokinase/phosphohydrolase (SpoT/RelA),
 - tyrosine and phenol metabolism operon regulators (TyrR),
 - several  uncharacterized  proteins  from  archaea, bacteria and plants that
   contain from one to four copies of this domain [2].

The ACT domain forms a beta-sheet with appressed helices (see <PDB:1PSD>) [1].

Threonine dehydratases  (TDs)  contain  an  ACT-like  regulatory  domain  that
possesses structural, rather than sequence, homology to the ACT domain [3].

The profile we developed cover the entire ACT and ACT-like domains.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: April 2013 / First entry.

[ 1] Aravind L., Koonin E.V.
     "Gleaning non-trivial structural, functional and evolutionary
     information about proteins by iterative database searches."
     J. Mol. Biol. 287:1023-1040(1999).
     PubMed=10222208; DOI=10.1006/jmbi.1999.2653
[ 2] Hsieh M.-H., Goodman H.M.
     "Molecular characterization of a novel gene family encoding ACT domain
     repeat proteins in Arabidopsis."
     Plant Physiol. 130:1797-1806(2002).
     PubMed=12481063; DOI=10.1104/pp.007484
[ 3] Chipman D.M., Shaanan B.
     "The ACT domain family."
     Curr. Opin. Struct. Biol. 11:694-700(2001).
     PubMed=11751050

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{END}