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	PROSITE documentation PDOC51674

Members of the WhiB-like (Wbl) family are found exclusively in actinobacteria and are implicated in the regulation of developmental processes. All WhiB-like proteins have four conserved cysteine residues where two of them are in a C-X-X-C motif. The four cysteine residues are proposed to act as the ligands for a [4Fe-4S] cluster. Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster [1,2,3].

The profile we developed covers the entire Wbl-type 4Fe-4S domain.

Last update:

May 2013 / First entry.

PROSITE method (with tools and information) covered by this documentation:

4FE4S_WBL, PS51674; 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 25
  • detected by PS51674: 25 (true positives)
  • undetected by PS51674: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS51674:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS51674
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51674
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51674
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS51674
• View ligand binding statistics of PS51674

1	Authors	Garg S.K., Suhail Alam M., Soni V., Radha Kishan K.V., Agrawal P.
	Title	Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase.
	Source	Protein Expr. Purif. 52:422-432(2007).
	PubMed ID	17157031
	DOI	10.1016/j.pep.2006.10.015

2	Authors	den Hengst C.D., Buttner M.J.
	Title	Redox control in actinobacteria.
	Source	Biochim. Biophys. Acta 1780:1201-1216(2008).
	PubMed ID	18252205
	DOI	10.1016/j.bbagen.2008.01.008

3	Authors	Smith L.J., Stapleton M.R., Buxton R.S., Green J.
	Title	Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.
	Source	PLoS ONE 7:E40407-E40407(2012).
	PubMed ID	22792304
	DOI	10.1371/journal.pone.0040407

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