{PDOC51697}
{PS51697; ALOG}
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* ALOG domain profile *
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The 125-residue  ALOG  (Arabidopsis LSH1 and oryza G1) domain is rich in basic
amino acids,  especially  arginine, and is highly conserved among land plants.
Members of   the  ALOG  family  of  proteins  function  as  key  developmental
regulators. It  has  been proposed that the ALOG domain originated from the N-
terminal DNA-binding   domains   of   integrases  belonging  to  the  tyrosine
recombinase superfamily   encoded   by  a  distinct  type  of  DIRS1-like  LTR
retrotransposon found  in  several eukaryotes. Secondary structure predictions
revealed an all-alpha helical domain with four conserved helices [1,2].

Some proteins known to contain an ALOG domain are listed below:

 - Arabidopsis  thaliana LIGHT_DEPENDENT SHORT HYPOCOTYLS1 (LSH1), involved in
   phytochrome-dependent light signaling.
 - Oryza G1, involved in the specification of sterile lemma identity.
 - Plant defence proteins.

The profile we developed covers the entire ALOG domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2013 / First entry.

[ 1] Yoshida A., Suzaki T., Tanaka W., Hirano H.-Y.
     "The homeotic gene long sterile lemma (G1) specifies sterile lemma
     identity in the rice spikelet."
     Proc. Natl. Acad. Sci. U.S.A. 106:20103-20108(2009).
     PubMed=19901325; DOI=10.1073/pnas.0907896106
[ 2] Iyer L.M., Aravind L.
     "ALOG domains: provenance of plant homeotic and developmental
     regulators from the  DNA-binding domain of a novel class of DIRS1-type
     retroposons."
     Biol. Direct 7:39-39(2012).
     PubMed=23146749; DOI=10.1186/1745-6150-7-39

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