{PDOC51738}
{PS51738; PEPTIDASE_C21}
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* Peptidase family C21 domain profile *
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The family  Tymoviridae  comprises  the genus Tymovirus, from which it derives
its name,  the  genus Marafivirus and the genus Maculavirus [1,E1]. Members of
the family  are  plant  viruses  that  have  the  following  traits in common:
icosahedral virion  structure, a monopartite single-stranded RNA genome with a
very high  cytidine content and a similar genome organization. The replication
strategy encompasses    post-translational   proteolytic   cleavage   of   the
polypeptide encoded  by  ORF1  by  a  peptidase  family  C21  domain [E2]. The
peptidase family  C21  domain  is  a  papain-like  proteinase  with  catalytic
cysteine and histidine residues [2,3].

Some proteins known to contain a peptidase family C21 domain are listed below:

 - Turnip yellow mosaic virus (TYMV) replication-associated polyprotein (RP).
 - Grapevine fleck virus (GFkV) replication-associated polyprotein (RP).
 - Oat blue dwarf virus (OBDV) replication-associated polyprotein (RP).
 - Maize rayado fino virus (MRFV) replication-associated polyprotein (RP).
 - Olive latent virus 3 (OLV-3) replication-associated polyprotein (RP).
 - Eggplant mosaic virus (EMV) replication-associated polyprotein (RP).
 - Ononis yellow mosaic virus (OYMV) replication-associated polyprotein (RP).
 - Kennedya  yellow  mosaic  virus  (KYMV)  replication-associated polyprotein
   (RP).
 - Erysimum latent virus (ELV) replication-associated polyprotein (RP).

The profile we developed covers the entire peptidase family C21 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2014 / First entry.

[ 1] Martelli G.P., Sabanadzovic S., Abou-Ghanem Sabanadzovic N.,
     Edwards M.C., Dreher T.
     "The family Tymoviridae."
     Arch. Virol. 147:1837-1846(2002).
     PubMed=12209322; DOI=10.1007/s007050200045
[ 2] Bransom K.L., Dreher T.W.
     "Identification of the essential cysteine and histidine residues of
     the turnip yellow mosaic virus protease."
     Virology 198:148-154(1994).
     PubMed=8037790; DOI=10.1006/viro.1994.1017
[ 3] Alabdullah A., Minafra A., Elbeaino T., Saponari M., Savino V.,
     Martelli G.P.
     "Complete nucleotide sequence and genome organization of Olive latent
     virus 3, a new putative member of the family Tymoviridae."
     Virus Res. 152:10-18(2010).
     PubMed=20561953; DOI=10.1016/j.virusres.2010.05.010
[E1] https://viralzone.expasy.org/54?outline=all_by_protein
[E2] https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c21

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