{PDOC51804}
{PS51804; ZF_C2HC_LYAR}
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* Zinc finger C2HC LYAR-type profile *
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Zinc finger  (ZF)  proteins are a large family of metalloproteins that utilize
zinc for  structural  purposes.  Zinc coordinates to a combination of cysteine
thiol and  histidine  imidazole  residues  within  the  ZF polypetide sequence
resulting in  a  folded  and  functional protein. Ly-1 antibody reactive clone
(Lyar), which  is  known  to  be expressed abundantly in the testis, encodes a
nucleolar protein  that  contain  a LYAR-type C2HC zinc finger motif and three
nuclear localization  signals.  It is a nucleolar protein abundantly expressed
in spermatocytes  and spermatids, but not sperm. LYAR forms a complex with the
nucleolin, which  is  one  of  the  most  abundant  proteins  in the nucleolus
[1,2,3].

The profile we developed covers the entire LYAR-type C2HC zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2016 / First entry.

[ 1] Su L., Hershberger R.J., Weissman I.L.
     "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs,
     is involved  in cell growth regulation."
     Genes Dev. 7:735-748(1993).
     PubMed=8491376
[ 2] Lee B., Jin S., Choi H., Kwon J.T., Kim J., Jeong J., Kwon Y.-I.,
     Cho C.
     "Expression and function of the testis-predominant protein LYAR in
     mice."
     Mol. Cells 35:54-60(2013).
     PubMed=23212345; DOI=10.1007/s10059-013-2271-3
[ 3] Yonezawa K., Sugihara Y., Oshima K., Matsuda T., Nadano D.
     "Lyar, a cell growth-regulating zinc finger protein, was identified to
     be associated with cytoplasmic ribosomes in male germ and cancer
     cells."
     Mol. Cell. Biochem. 395:221-229(2014).
     PubMed=24990247; DOI=10.1007/s11010-014-2128-x

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