{PDOC51811}
{PS51811; ZF_CCHC_HIVEP}
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* Zinc finger CCHC HIVEP-type profile *
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The HIVEP  family  of  zinc finger (Znf) proteins regulates a diverse array of
developmental and  biological processes through direct DNA binding, as well as
interaction with   other   transcription  factors  and  components  of  signal
transduction pathways. Three vertebrate paralogous genes have been identified,
HIVEP (also  called  ZAS  or Shn)-1, -2 and -3, as well as the closely related
Drosophila gene,  Schnurri. HIVEP and the Drosophila Schnurri proteins contain
two pairs  of  C2H2  Znf  and,  with  the  exception  of  the HIVEP2 family, a
conserved CCHC-type Znf. In addition, Drosophila Schnurri contains a conserved
carboxyl-terminal Znf  triplet  that  is  not found in the vertebrate members.
Sequence conservation  between  vertebrate  HIVEP  and the Drosophila Schnurri
proteins is  generally  low  with  the exception of the two pairs of C2H2 Znf,
which are highly conserved [1].

The profile we developed covers the entire HIVEP-type CCHC zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: September 2016 / First entry.

[ 1] Duerr U., Henningfeld K.A., Hollemann T., Knoechel W., Pieler T.
     "Isolation and characterization of the Xenopus HIVEP gene family."
     Eur. J. Biochem. 271:1135-1144(2004).
     PubMed=15009192

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