{PDOC51820} {PS51820; PA14} {BEGIN} *********************** * PA14 domain profile * *********************** The ~150-amino acid PA14 domain, named after its location in the protective antigen of anthrax toxin, is found in a variety of bacterial and eukaryotic proteins such as glycosidases, glycosyltransferases, proteases, amidases, toxins, adhesins and signaling molecules. The PA14 domain is combined in a mosaic manner with various catalytic or non-catalytic domains directly or indirectly implicated in binding carbohydrate or peptidoglycan. It could be a carbohydrate-binding module [1,2,3]. The PA14 domain is a beta-barrel structure comprising two beta-sheets (see ). The N and C termini of the domain are close together in space, presumably, thereby facilitating the insertion of the PA14 domain into other recognized domains without structural disruption [1,2,3]. The profile we developed covers the entire PA14 domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 2016 / First entry. [ 1] Rigden D.J., Mello L.V., Galperin M.Y. "The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules." Trends Biochem. Sci. 29:335-339(2004). PubMed=15236739; DOI=10.1016/j.tibs.2004.05.002 [ 2] Yoshida E., Hidaka M., Fushinobu S., Koyanagi T., Minami H., Tamaki H., Kitaoka M., Katayama T., Kumagai H. "Role of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 beta-glucosidase from Kluyveromyces marxianus." Biochem. J. 431:39-49(2010). PubMed=20662765; DOI=10.1042/BJ20100351 [ 3] Petosa C., Collier R.J., Klimpel K.R., Leppla S.H., Liddington R.C. "Crystal structure of the anthrax toxin protective antigen." Nature 385:833-838(1997). PubMed=9039918; DOI=10.1038/385833a0 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}