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Entry: PS00063

General information about the entry

Entry name [info] ALDOKETO_REDUCTASE_3
Accession [info] PS00063
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00061

Name and characterization of the entry

Description [info] Aldo/keto reductase family putative active site signature.
Pattern [info]
[LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x-
{LVRI}-[LIVMFA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 172 in 172 different sequences
Number of true positive hits 119 in 119 different sequences
Number of 'unknown' hits 0
Number of false positive hits 53 in 53 different sequences
Number of false negative sequences 71
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 69.19 %
Recall (true positives / (true positives + false negatives)) 62.63 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 8
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
119 sequences

6DCS_SOYBN  (P26690    ), A1A1A_DANRE (Q6AZW2    ), A1A1B_DANRE (Q568L5    ), 
AK1A1_BOVIN (Q3ZCJ2    ), AK1A1_CHICK (Q5ZK84    ), AK1A1_HUMAN (P14550    ), 
AK1A1_MOUSE (Q9JII6    ), AK1A1_PIG   (P50578    ), AK1A1_PONAB (Q5R5D5    ), 
AK1A1_RAT   (P51635    ), AK1A1_XENLA (Q6GMC7    ), AK1A1_XENTR (Q28FD1    ), 
AK1BA_HUMAN (O60218    ), AK1C1_HUMAN (Q04828    ), AK1C1_MACFA (Q95JH7    ), 
AK1C1_MACFU (Q95JH6    ), AK1C1_PONAB (Q5REQ0    ), AK1C2_HUMAN (P52895    ), 
AK1C3_HUMAN (P42330    ), AK1C3_PONAB (Q5R7C9    ), AK1C4_HUMAN (P17516    ), 
AK1C4_MACFA (Q95JH5    ), AK1C4_MACFU (Q95JH4    ), AK1CN_HORSE (Q1XAA8    ), 
AK1CO_HORSE (Q6W8P9    ), AK1D1_HUMAN (P51857    ), AK1D1_MOUSE (Q8VCX1    ), 
AK1D1_RABIT (Q9TV64    ), AK1D1_RAT   (P31210    ), AK2E4_BOMMO (H9JTG9    ), 
AKC1H_MOUSE (Q8K023    ), AKC1H_RAT   (P51652    ), AKCL2_MOUSE (Q9DCT1    ), 
AKCL2_PIG   (P82125    ), AKCL2_RAT   (Q5U1Y4    ), AKRC8_ARATH (O80944    ), 
AKRC9_ARATH (Q0PGJ6    ), AKRCA_ARATH (Q84TF0    ), AKRCB_ARATH (Q9M338    ), 
ALD1_MOUSE  (P21300    ), ALD2_CRIGR  (O08782    ), ALD2_MOUSE  (P45377    ), 
ALDR_BOVIN  (P16116    ), ALDR_HORVU  (P23901    ), ALDR_HUMAN  (P15121    ), 
ALDR_MOUSE  (P45376    ), ALDR_PIG    (P80276    ), ALDR_RABIT  (P15122    ), 
ALDR_RAT    (P07943    ), ALRB_DICDI  (Q54NZ7    ), ARA1_YEAST  (P38115    ), 
COR11_PAPSO (Q9SQ70    ), COR12_PAPSO (Q9SQ69    ), COR13_PAPSO (Q9SQ68    ), 
COR14_PAPSO (Q9SQ67    ), COR15_PAPSO (B9VRJ2    ), COR2_PAPSO  (Q9SQ64    ), 
CRO_LITCT   (P17264    ), CRO_RANTE   (P02532    ), DDBX_BOVIN  (P52898    ), 
DHB5_MOUSE  (P70694    ), DIDH_RAT    (P23457    ), DKGA_ECO57  (Q8XBT6    ), 
DKGA_ECOLI  (Q46857    ), DKGA_SALTI  (P58744    ), DKGA_SALTY  (Q8ZM06    ), 
DKGA_YERPE  (Q8ZI40    ), DKGB_CORSS  (P15339    ), DTDH_MUCMU  (Q01213    ), 
GAR1_HYPJE  (Q3ZFI7    ), GCY1_YEAST  (P14065    ), GLD2_HYPJE  (Q0GYU4    ), 
GRE3_YEAST  (P38715    ), GR_BACSU    (O32210    ), MER_ERYCB   (E7C196    ), 
MIOX_MOUSE  (Q9QXN5    ), MIOX_RAT    (Q9QXN4    ), MORA_PSEPU  (Q02198    ), 
MRP1_RAT    (Q8CG09    ), NADO1_ORYSJ (Q7G764    ), NADO2_ORYSJ (Q7G765    ), 
PE2R_RABIT  (P80508    ), PGFS1_BOVIN (P05980    ), PGFS2_BOVIN (P52897    ), 
PGFS_LEIMA  (P22045    ), PGFS_TRYCC  (Q4DJ07    ), S6PD_MALDO  (P28475    ), 
STORR_PAPSO (P0DKI7    ), XYL1_ARTOC  (C5FFQ7    ), XYL1_ASPCL  (A1CRI1    ), 
XYL1_ASPFC  (B0XNR0    ), XYL1_ASPFN  (B8N195    ), XYL1_ASPFU  (Q4WJT9    ), 
XYL1_ASPNC  (A2Q8B5    ), XYL1_ASPNG  (Q9P8R5    ), XYL1_ASPOR  (Q2UKD0    ), 
XYL1_ASPTN  (Q0CUL0    ), XYL1_CANBO  (Q8X195    ), XYL1_CANPA  (Q6Y0Z3    ), 
XYL1_CANTE  (O74237    ), XYL1_CANTR  (O13283    ), XYL1_EMENI  (Q5BGA7    ), 
XYL1_NEOFI  (A1D4E3    ), XYL1_PICGU  (O94735    ), XYL1_PICST  (P31867    ), 
XYL1_SCHSH  (Q9P430    ), XYL2_CANTR  (P87039    ), Y1918_MYCSJ (A3PXS9    ), 
Y1919_MYCSJ (A3PXT0    ), Y1938_MYCSS (Q1BAN7    ), Y1984_MYCSK (A1UEC5    ), 
Y1985_MYCSK (A1UEC6    ), Y2408_MYCS2 (A0QV10    ), Y4205_MYCGI (A4TE41    ), 
YER5_SCHPO  (O14088    ), YJ66_YEAST  (P47137    ), YOF5_CAEEL  (Q09632    ), 
YPR1_YEAST  (Q12458    ), YTBE_BACSU  (O34678    )
» more

UniProtKB/Swiss-Prot
False negative sequences
71 sequences

AK1BF_HUMAN (C9JRZ8    ), AK1CD_MESAU (P82809    ), AK1CD_MOUSE (Q8VC28    ), 
AK1CL_MOUSE (Q91WR5    ), AK1CL_RAT   (Q6AYQ2    ), AKCL1_HUMAN (Q5T2L2    ), 
AKCL2_HUMAN (Q96JD6    ), AKCL2_MACFA (Q4R802    ), AKR1_ORYSI  (B8ASB2    ), 
AKR1_ORYSJ  (Q0JE32    ), AKR1_SOYBN  (C6TBN2    ), AKR2_ORYSI  (A2XRZ0    ), 
AKR2_ORYSJ  (Q7XT99    ), AKR3_ORYSI  (A2XRZ6    ), AKR3_ORYSJ  (Q7XQ45    ), 
AKRMG_ECOLI (P77256    ), AKR_SYNY3   (P74308    ), ALDX_SPOSA  (P27800    ), 
ALKR1_ARATH (Q9C5B9    ), ALKR2_ARATH (Q84M96    ), ALKR3_ARATH (O22707    ), 
ALKR4_ARATH (Q93ZN2    ), ALKR5_ARATH (Q9ASZ9    ), ALKR6_ARATH (F4HPY8    ), 
ALRA_DICDI  (Q6IMN8    ), ALRC_DICDI  (Q55FL3    ), ARA2_YEAST  (Q04212    ), 
DKGA_CORSC  (P06632    ), DKGB_ECO57  (Q8X7Z7    ), DKGB_ECOLI  (P30863    ), 
DKGB_SALTI  (Q8Z988    ), DKGB_SALTY  (Q8ZRM7    ), DKGB_YERPE  (Q8ZH36    ), 
FCDH_PSESP  (Q52472    ), GALDH_ARATH (O81884    ), GLD1_HYPJE  (Q0GYU5    ), 
GS69_BACSU  (P80874    ), I3ACR_SCHPO (O13848    ), IOLS_BACSU  (P46336    ), 
KAR_YEAST   (Q07551    ), MORA_RABIT  (P82810    ), PERR_RAUSE  (Q3L181    ), 
PGFS_TRYBB  (Q9GV41    ), PLR1_SCHPO  (O14295    ), PLR1_YEAST  (Q06494    ), 
PLR2_SCHPO  (O94521    ), PRD1_MAGO7  (G4MZI3    ), XYL1_HYPJE  (Q876L8    ), 
XYL1_KLULA  (P49378    ), XYL1_MAGO7  (G4N708    ), XYL1_PACTA  (P78736    ), 
Y1669_MYCLB (B8ZS00    ), Y1669_MYCLE (O69462    ), Y1744_MYCMM (B2HIJ9    ), 
Y1987_MYCUA (A0PQ11    ), Y2161_MYCVP (A1T726    ), Y2407_MYCS2 (A0QV09    ), 
Y2971_MYCTO (P9WQA4    ), Y2971_MYCTU (P9WQA5    ), Y2993_MYCBP (A1KMW6    ), 
Y2996_MYCBO (Q7TXI6    ), Y2999_MYCTA (A5U6Y1    ), Y3007_MYCPA (Q73VK6    ), 
Y3816_MYCA1 (A0QJ99    ), Y4149_MYCPA (Q73SC5    ), Y4483_MYCA1 (A0QL30    ), 
YBN4_SCHPO  (O42888    ), YDG7_SCHPO  (Q10494    ), YEZB_SCHPO  (O14125    ), 
YH5B_SCHPO  (O94315    ), YKW2_SCHPO  (Q9C1X5    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

CROB_LEPLU  (P49261    ), DHGP_ASPNG  (P55804    )

		
UniProtKB/Swiss-Prot
False positive sequences
53 sequences

AAP1_ARATH  (Q42400    ), AAP6_ARATH  (P92934    ), ATPFD_MYCA9 (B1MLV9    ), 
BST1_ASHGO  (Q752Q2    ), CK024_HUMAN (Q96F05    ), EIF3C_ASPOR (Q2U0Q9    ), 
EIF3C_ASPTN (Q0CVT0    ), EIF3C_BOMMO (Q0ZB76    ), FAD3_RICPR  (Q9ZCZ1    ), 
FGFP3_MOUSE (Q1HCM0    ), H34_TETTS   (Q22RG7    ), HMUV_PHOLL  (Q7N3S7    ), 
LPIN2_MOUSE (Q99PI5    ), MACB2_PSEPF (Q3KE48    ), MURC_BART1  (A9IWA4    ), 
MUTS_AGRFC  (Q8UIF2    ), MUTS_AZOC5  (A8I275    ), MUTS_BARHE  (Q6G542    ), 
MUTS_BARQU  (Q6G0X1    ), MUTS_BART1  (A9ILT1    ), MUTS_BRUA2  (Q2YNZ0    ), 
MUTS_BRUAB  (Q57FM9    ), MUTS_BRUC2  (A9M792    ), MUTS_BRUME  (Q8YES6    ), 
MUTS_BRUO2  (A5VN83    ), MUTS_BRUSI  (B0CIQ5    ), MUTS_BRUSU  (Q8G310    ), 
MUTS_CHESB  (Q11B27    ), MUTS_OCHA4  (A6WV86    ), MUTS_RHIEC  (Q2KD76    ), 
MUTS_RHIL3  (Q1MMA5    ), NAGS_NEUCR  (Q1K8F6    ), NAGS_PODAN  (B2B2C5    ), 
NUP85_ARATH (Q8RXH2    ), PB1_CHICK   (Q90941    ), PB1_HUMAN   (Q86U86    ), 
PTA_DEIGD   (Q1J2D0    ), RL13_SULSO  (P95991    ), RR18_GRATL  (Q6B8S1    ), 
RR18_TETOB  (Q1KVT1    ), RS18_THET2  (P62659    ), RS18_THET8  (Q5SLQ0    ), 
RS18_THETH  (P80382    ), SECA_PHATC  (A0T0G5    ), SYE_LACGA   (Q045X9    ), 
SYE_LACJO   (Q74L27    ), TRMB_CAMFF  (A0RQ93    ), U507_KLULA  (Q6CSG8    ), 
XERC_RICPR  (Q9ZCE0    ), XERC_RICTY  (Q68VT2    ), Y109_OSHVF  (Q6R7C1    ), 
Y2014_VIBVU (Q8DB14    ), Y2402_VIBVY (Q7MIW1    )
» more

PDB
[Detailed view]
263 PDB

1ABN; 1ADS; 1AE4; 1AFS; 1AH0; 1AH3; 1AH4; 1AZ1; 1AZ2; 1C9W; 1CWN; 1DLA; 1EF3; 1EKO; 1EL3; 1FRB; 1HQT; 1IEI; 1IHI; 1J96; 1JEZ; 1K8C; 1LWI; 1MAR; 1MI3; 1MRQ; 1MZR; 1PWL; 1PWM; 1Q13; 1Q5M; 1R38; 1RAL; 1RY0; 1RY8; 1S1P; 1S1R; 1S2A; 1S2C; 1SM9; 1T40; 1T41; 1US0; 1X96; 1X97; 1X98; 1XF0; 1XJB; 1YE4; 1YE6; 1Z3N; 1Z89; 1Z8A; 1Z9A; 1ZQ5; 1ZUA; 2ACQ; 2ACR; 2ACS; 2ACU; 2AGT; 2ALR; 2BGQ; 2BGS; 2DUX; 2DUZ; 2DV0; 2F2K; 2F38; 2FGB; 2FVL; 2FZ8; 2FZ9; 2FZB; 2FZD; 2HDJ; 2HV5; 2HVN; 2HVO; 2I16; 2I17; 2IKG; 2IKH; 2IKI; 2IKJ; 2INE; 2INZ; 2IPJ; 2IPW; 2IQ0; 2IQD; 2IS7; 2ISF; 2J8T; 2NVC; 2NVD; 2PD5; 2PD9; 2PDB; 2PDC; 2PDF; 2PDG; 2PDH; 2PDI; 2PDJ; 2PDK; 2PDL; 2PDM; 2PDN; 2PDP; 2PDQ; 2PDU; 2PDW; 2PDX; 2PDY; 2PEV; 2PF8; 2PFH; 2PZN; 2QXW; 2R24; 2VDG; 3B3D; 3BCJ; 3BUR; 3BUV; 3BV7; 3C3U; 3CAQ; 3CAS; 3CAV; 3CMF; 3COT; 3CV7; 3D3F; 3DN5; 3DOP; 3F7J; 3FX4; 3G1R; 3G5E; 3GHR; 3GHS; 3GHT; 3GHU; 3GUG; 3H4G; 3H7R; 3H7U; 3LBO; 3LD5; 3LEN; 3LEP; 3LQG; 3LQL; 3LZ3; 3LZ5; 3M0I; 3M4H; 3M64; 3MB9; 3MC5; 3NTY; 3ONB; 3ONC; 3P2V; 3Q65; 3Q67; 3R43; 3R58; 3R6I; 3R7M; 3R8G; 3R8H; 3R94; 3RX2; 3RX3; 3RX4; 3S3G; 3T42; 3U2C; 3UFY; 3UG8; 3UGR; 3UWE; 3UZW; 3UZX; 3UZY; 3UZZ; 3V35; 3V36; 3WCZ; 4DBS; 4DBU; 4DBW; 4DZ5; 4F40; 4FA3; 4FAL; 4FAM; 4FZI; 4G5D; 4GA8; 4GAB; 4GAC; 4GCA; 4GIE; 4GQ0; 4GQG; 4H7C; 4HMN; 4I5X; 4IGS; 4IJC; 4IJR; 4JIH; 4JII; 4JIR; 4JQ1; 4JQ2; 4JQ3; 4JQ4; 4JQA; 4JTQ; 4JTR; 4L1W; 4L1X; 4LAU; 4LAZ; 4LB3; 4LB4; 4LBR; 4LBS; 4NKC; 4PR4; 4PRR; 4PRT; 4PUU; 4PUW; 4Q7B; 4QBX; 4QR6; 4QX4; 4QXI; 4RPQ; 4WDT; 4WDU; 4WDW; 4WDX; 4WRH; 4XO6; 4XO7; 4XVD; 4XVE; 4XZH; 4XZI; 4YS1; 4YU1; 4YVP; 4YVV; 4YVX; 4ZFC; 5HA7
» more

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