Entry: PS00063
General information about the entry
Entry nameALDOKETO_REDUCTASE_3
Accession numberPS00063
Entry typePATTERN
DateAPR-1990 (CREATED); APR-2006 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE DocumentationPDOC00061
Name and characterization of the entry
DescriptionAldo/keto reductase family putative active site signature.
Pattern[LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x- {LVRI}-[LIVMFA].
Numerical results
  • UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242.
  • Total number of hits in UniProtKB/Swiss-Prot: 160 hits in 160 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 107 hits in 107 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 53 hits in 53 different sequences
  • Number of known missed hits: 47
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 2
  • Precision (true hits / (true hits + false positives)): 66.88 %
  • Recall (true hits / (true hits + false negatives)): 69.48 %
Comments
  • Taxonomic range: Eukaryotes, Prokaryotes (Bacteria)
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 8,active_site(?)
  • VERSION: 2
Cross-references
UniProtKB/Swiss-ProtTrue positive hits:
6DCS_SOYBN  (P26690), A1A1A_DANRE (Q6AZW2), A1A1B_DANRE (Q568L5), 
AK1A1_BOVIN (Q3ZCJ2), AK1A1_CHICK (Q5ZK84), AK1A1_HUMAN (P14550), 
AK1A1_MOUSE (Q9JII6), AK1A1_PIG   (P50578), AK1A1_PONAB (Q5R5D5), 
AK1A1_RAT   (P51635), AK1A1_XENLA (Q6GMC7), AK1A1_XENTR (Q28FD1), 
AK1BA_HUMAN (O60218), AK1C1_HUMAN (Q04828), AK1C1_MACFA (Q95JH7), 
AK1C1_MACFU (Q95JH6), AK1C1_PONAB (Q5REQ0), AK1C2_HUMAN (P52895), 
AK1C3_HUMAN (P42330), AK1C3_PONAB (Q5R7C9), AK1C4_HUMAN (P17516), 
AK1C4_MACFA (Q95JH5), AK1C4_MACFU (Q95JH4), AK1CN_HORSE (Q1XAA8), 
AK1CO_HORSE (Q6W8P9), AK1D1_HUMAN (P51857), AK1D1_MOUSE (Q8VCX1), 
AK1D1_RABIT (Q9TV64), AK1D1_RAT   (P31210), AKC1H_MOUSE (Q8K023), 
AKC1H_RAT   (P51652), AKCL2_MOUSE (Q9DCT1), AKCL2_PIG   (P82125), 
AKCL2_RAT   (Q5U1Y4), AKRC8_ARATH (O80944), AKRC9_ARATH (Q0PGJ6), 
AKRCA_ARATH (Q84TF0), AKRCB_ARATH (Q9M338), ALD1_MOUSE  (P21300), 
ALD2_CRIGR  (O08782), ALD2_MOUSE  (P45377), ALDR_BOVIN  (P16116), 
ALDR_HORVU  (P23901), ALDR_HUMAN  (P15121), ALDR_MOUSE  (P45376), 
ALDR_PIG    (P80276), ALDR_RABIT  (P15122), ALDR_RAT    (P07943), 
ALRB_DICDI  (Q54NZ7), ARA1_YEAST  (P38115), CRO_RANCA   (P17264), 
CRO_RANTE   (P02532), DDBX_BOVIN  (P52898), DHB5_MOUSE  (P70694), 
DIDH_RAT    (P23457), DKGA_ECO57  (Q8XBT6), DKGA_ECOLI  (Q46857), 
DKGA_SALTI  (P58744), DKGA_SALTY  (Q8ZM06), DKGA_YERPE  (Q8ZI40), 
DKGB_CORSS  (P15339), DTDH_MUCMU  (Q01213), GCY_YEAST   (P14065), 
GRE3_YEAST  (P38715), GR_BACSU    (O32210), MIOX_MOUSE  (Q9QXN5), 
MIOX_RAT    (Q9QXN4), MORA_PSEPU  (Q02198), MRP1_RAT    (Q8CG09), 
NADO1_ORYSJ (Q7G764), NADO2_ORYSJ (Q7G765), P100_LEIMA  (P22045), 
PE2R_RABIT  (P80508), PGFS1_BOVIN (P05980), PGFS2_BOVIN (P52897), 
S6PD_MALDO  (P28475), XYL1_ARTOC  (C5FFQ7), XYL1_ASPCL  (A1CRI1), 
XYL1_ASPFC  (B0XNR0), XYL1_ASPFN  (B8N195), XYL1_ASPFU  (Q4WJT9), 
XYL1_ASPNC  (A2Q8B5), XYL1_ASPNG  (Q9P8R5), XYL1_ASPOR  (Q2UKD0), 
XYL1_ASPTN  (Q0CUL0), XYL1_CANBO  (Q8X195), XYL1_CANPA  (Q6Y0Z3), 
XYL1_CANSH  (Q9P430), XYL1_CANTE  (O74237), XYL1_CANTR  (O13283), 
XYL1_EMENI  (Q5BGA7), XYL1_NEOFI  (A1D4E3), XYL1_PICGU  (O94735), 
XYL1_PICST  (P31867), XYL2_CANTR  (P87039), Y1918_MYCSJ (A3PXS9), 
Y1919_MYCSJ (A3PXT0), Y1938_MYCSS (Q1BAN7), Y1984_MYCSK (A1UEC5), 
Y1985_MYCSK (A1UEC6), Y2408_MYCS2 (A0QV10), Y4205_MYCGI (A4TE41), 
YER5_SCHPO  (O14088), YJ66_YEAST  (P47137), YOF5_CAEEL  (Q09632), 
YPR1_YEAST  (Q12458), YTBE_BACSU  (O34678)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
AK1BF_HUMAN (C9JRZ8), AK1CD_MESAU (P82809), AK1CD_MOUSE (Q8VC28), 
AK1CL_MOUSE (Q91WR5), AK1CL_RAT   (Q6AYQ2), AKCL1_HUMAN (Q5T2L2), 
AKCL2_HUMAN (Q96JD6), AKCL2_MACFA (Q4R802), ALDX_SPOSA  (P27800), 
ALRA_DICDI  (Q6IMN8), ALRC_DICDI  (Q55FL3), ARA2_YEAST  (Q04212), 
DKGA_CORSC  (P06632), DKGB_ECO57  (Q8X7Z7), DKGB_ECOLI  (P30863), 
DKGB_SALTI  (Q8Z988), DKGB_SALTY  (Q8ZRM7), DKGB_YERPE  (Q8ZH36), 
FCDH_PSESP  (Q52472), I3ACR_SCHPO (O13848), KAR_YEAST   (Q07551), 
MORA_RABIT  (P82810), PLR1_SCHPO  (O14295), PLR1_YEAST  (Q06494), 
PLR2_SCHPO  (O94521), XYL1_HYPJE  (Q876L8), XYL1_KLULA  (P49378), 
XYL1_PACTA  (P78736), Y1669_MYCLB (B8ZS00), Y1669_MYCLE (O69462), 
Y1744_MYCMM (B2HIJ9), Y1987_MYCUA (A0PQ11), Y2161_MYCVP (A1T726), 
Y2407_MYCS2 (A0QV09), Y2971_MYCTU (P95124), Y2993_MYCBP (A1KMW6), 
Y2996_MYCBO (Q7TXI6), Y2999_MYCTA (A5U6Y1), Y3007_MYCPA (Q73VK6), 
Y3816_MYCA1 (A0QJ99), Y4149_MYCPA (Q73SC5), Y4483_MYCA1 (A0QL30), 
YBN4_SCHPO  (O42888), YDG7_SCHPO  (Q10494), YEZB_SCHPO  (O14125), 
YH5B_SCHPO  (O94315), YKW2_SCHPO  (Q9C1X5)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
CROB_LEPLU  (P49261), DHGP_ASPNG  (P55804)
False positive hits (sequences which do not belong to the set under consideration):
AAP1_ARATH  (Q42400), AAP6_ARATH  (P92934), ATPFD_MYCA9 (B1MLV9), 
BST1_ASHGO  (Q752Q2), CK024_HUMAN (Q96F05), EIF3C_ASPOR (Q2U0Q9), 
EIF3C_ASPTN (Q0CVT0), EIF3C_BOMMO (Q0ZB76), FAD3_RICPR  (Q9ZCZ1), 
FGFP3_MOUSE (Q1HCM0), H34_TETTS   (Q22RG7), HMUV_PHOLL  (Q7N3S7), 
LPIN2_MOUSE (Q99PI5), MACB2_PSEPF (Q3KE48), MURC_BART1  (A9IWA4), 
MUTS_AGRT5  (Q8UIF2), MUTS_AZOC5  (A8I275), MUTS_BARHE  (Q6G542), 
MUTS_BARQU  (Q6G0X1), MUTS_BART1  (A9ILT1), MUTS_BRUA2  (Q2YNZ0), 
MUTS_BRUAB  (Q57FM9), MUTS_BRUC2  (A9M792), MUTS_BRUME  (Q8YES6), 
MUTS_BRUO2  (A5VN83), MUTS_BRUSI  (B0CIQ5), MUTS_BRUSU  (Q8G310), 
MUTS_MESSB  (Q11B27), MUTS_OCHA4  (A6WV86), MUTS_RHIEC  (Q2KD76), 
MUTS_RHIL3  (Q1MMA5), NAGS_NEUCR  (Q1K8F6), NAGS_PODAN  (B2B2C5), 
NUP85_ARATH (Q8RXH2), PB1_CHICK   (Q90941), PB1_HUMAN   (Q86U86), 
PTA_DEIGD   (Q1J2D0), RL13_SULSO  (P95991), RR18_GRATL  (Q6B8S1), 
RR18_SCEOB  (Q1KVT1), RS18_THET2  (P62659), RS18_THET8  (Q5SLQ0), 
RS18_THETH  (P80382), SECA_PHATC  (A0T0G5), SYE_LACGA   (Q045X9), 
SYE_LACJO   (Q74L27), TRMB_CAMFF  (A0RQ93), U507_KLULA  (Q6CSG8), 
XERC_RICPR  (Q9ZCE0), XERC_RICTY  (Q68VT2), Y109_OSHVF  (Q6R7C1), 
Y2014_VIBVU (Q8DB14), Y2402_VIBVY (Q7MIW1)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]
1ABN; 1ADS; 1AE4; 1AFS; 1AH0; 1AH3; 1AH4; 1AZ1; 1AZ2; 1C9W; 1CWN; 1DLA; 1EF3; 1EKO; 1EL3; 1FRB; 1HQT; 1IEI; 1IHI; 1J96; 1JEZ; 1K8C; 1LLG; 1LWI; 1MAR; 1MI3; 1MRQ; 1MZR; 1PWL; 1PWM; 1Q13; 1Q5M; 1R38; 1RAL; 1RY0; 1RY8; 1S1P; 1S1R; 1S2A; 1S2C; 1SM9; 1T40; 1T41; 1US0; 1X96; 1X97; 1X98; 1XF0; 1XJB; 1YE4; 1YE6; 1Z3N; 1Z89; 1Z8A; 1Z9A; 1ZQ5; 1ZUA; 2ACQ; 2ACR; 2ACS; 2ACU; 2AGT; 2ALR; 2AR4; 2BGQ; 2BGS; 2DUX; 2DUZ; 2DV0; 2F2K; 2F38; 2FGB; 2FVL; 2FZ8; 2FZ9; 2FZB; 2FZD; 2GO6; 2HDJ; 2HV5; 2HVN; 2HVO; 2I16; 2I17; 2IKG; 2IKH; 2IKI; 2IKJ; 2INE; 2INZ; 2IPJ; 2IPW; 2IQ0; 2IQD; 2IS7; 2ISF; 2J8T; 2NVC; 2NVD; 2PD5; 2PD9; 2PDB; 2PDC; 2PDF; 2PDG; 2PDH; 2PDI; 2PDJ; 2PDK; 2PDL; 2PDM; 2PDN; 2PDP; 2PDQ; 2PDU; 2PDW; 2PDX; 2PDY; 2PEV; 2PF8; 2PFH; 2PZN; 2QXW; 2R24; 2VDG; 3B3D; 3BCJ; 3BUR; 3BUV; 3BV7; 3C3U; 3CAQ; 3CAS; 3CAV; 3CMF; 3COT; 3CV7; 3D3F; 3DN5; 3DOP; 3F7J; 3FX4; 3G1R; 3G5E; 3GHR; 3GHS; 3GHT; 3GHU; 3GUG; 3H4G; 3H7R; 3H7U; 3LBO; 3LD5; 3LEN; 3LEP; 3LQG; 3LQL; 3LZ3; 3LZ5; 3M0I; 3M4H; 3M64; 3MB9; 3MC5; 3NTY; 3ONB; 3ONC; 3P2V; 3Q65; 3Q67; 3RX2; 3RX3; 3RX4; 3T42; 3U2C;

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