ID   ALDOKETO_REDUCTASE_3; PATTERN.
AC   PS00063;
DT   01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
DE   Aldo/keto reductase family putative active site signature.
PA   [LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x-
PA   {LVRI}-[LIVMFA].
NR   /RELEASE=2024_02,571282;
NR   /TOTAL=190(190); /POSITIVE=127(127); /UNKNOWN=0(0); /FALSE_POS=63(63);
NR   /FALSE_NEG=73; /PARTIAL=2;
CC   /TAXO-RANGE=??EP?; /MAX-REPEAT=1;
CC   /SITE=8,active_site(?);
CC   /VERSION=2;
DR   P26690    , 6DCS_SOYBN , T; Q6AZW2    , A1A1A_DANRE, T;
DR   Q568L5    , A1A1B_DANRE, T; Q3ZCJ2    , AK1A1_BOVIN, T;
DR   Q5ZK84    , AK1A1_CHICK, T; O70473    , AK1A1_CRIGR, T;
DR   P14550    , AK1A1_HUMAN, T; Q9JII6    , AK1A1_MOUSE, T;
DR   P50578    , AK1A1_PIG  , T; Q5R5D5    , AK1A1_PONAB, T;
DR   P51635    , AK1A1_RAT  , T; Q6GMC7    , AK1A1_XENLA, T;
DR   Q28FD1    , AK1A1_XENTR, T; O60218    , AK1BA_HUMAN, T;
DR   Q04828    , AK1C1_HUMAN, T; Q95JH7    , AK1C1_MACFA, T;
DR   Q95JH6    , AK1C1_MACFU, T; Q5REQ0    , AK1C1_PONAB, T;
DR   P52895    , AK1C2_HUMAN, T; P42330    , AK1C3_HUMAN, T;
DR   Q5R7C9    , AK1C3_PONAB, T; P17516    , AK1C4_HUMAN, T;
DR   Q95JH5    , AK1C4_MACFA, T; Q95JH4    , AK1C4_MACFU, T;
DR   D3ZF77    , AK1CA_RAT  , T; Q1XAA8    , AK1CN_HORSE, T;
DR   Q6W8P9    , AK1CO_HORSE, T; P51857    , AK1D1_HUMAN, T;
DR   Q8VCX1    , AK1D1_MOUSE, T; Q9TV64    , AK1D1_RABIT, T;
DR   P31210    , AK1D1_RAT  , T; H9JTG9    , AK2E4_BOMMO, T;
DR   Q8K023    , AKC1H_MOUSE, T; P51652    , AKC1H_RAT  , T;
DR   Q9DCT1    , AKCL2_MOUSE, T; P82125    , AKCL2_PIG  , T;
DR   Q5U1Y4    , AKCL2_RAT  , T; O80944    , AKRC8_ARATH, T;
DR   Q0PGJ6    , AKRC9_ARATH, T; Q84TF0    , AKRCA_ARATH, T;
DR   Q9M338    , AKRCB_ARATH, T; P21300    , ALD1_MOUSE , T;
DR   O08782    , ALD2_CRIGR , T; P45377    , ALD2_MOUSE , T;
DR   P16116    , ALDR_BOVIN , T; P23901    , ALDR_HORVU , T;
DR   P15121    , ALDR_HUMAN , T; P45376    , ALDR_MOUSE , T;
DR   P80276    , ALDR_PIG   , T; P15122    , ALDR_RABIT , T;
DR   P07943    , ALDR_RAT   , T; Q54NZ7    , ALRB_DICDI , T;
DR   P38115    , ARA1_YEAST , T; Q9SQ70    , COR11_PAPSO, T;
DR   Q9SQ69    , COR12_PAPSO, T; Q9SQ68    , COR13_PAPSO, T;
DR   Q9SQ67    , COR14_PAPSO, T; B9VRJ2    , COR15_PAPSO, T;
DR   Q9SQ64    , COR2_PAPSO , T; P17264    , CRO_AQUCT  , T;
DR   P02532    , CRO_RANTE  , T; P52898    , DDBX_BOVIN , T;
DR   P70694    , DHB5_MOUSE , T; P23457    , DIDH_RAT   , T;
DR   Q8XBT6    , DKGA_ECO57 , T; Q46857    , DKGA_ECOLI , T;
DR   P58744    , DKGA_SALTI , T; Q8ZM06    , DKGA_SALTY , T;
DR   Q8ZI40    , DKGA_YERPE , T; P15339    , DKGB_CORSS , T;
DR   Q0PCF4    , DMAS1_HORVU, T; B4F9A4    , DMAS1_MAIZE, T;
DR   Q10PE7    , DMAS1_ORYSJ, T; W5DYE3    , DMS1A_WHEAT, T;
DR   A0A1D5XGW0, DMS1B_WHEAT, T; A0A1X9QHJ0, DMS1D_WHEAT, T;
DR   Q01213    , DTDH_MUCMU , T; Q3ZFI7    , GAR1_HYPJE , T;
DR   P14065    , GCY1_YEAST , T; Q0GYU4    , GLD2_HYPJE , T;
DR   P38715    , GRE3_YEAST , T; O32210    , GR_BACSU   , T;
DR   E7C196    , MER_ERYCB  , T; Q9QXN5    , MIOX_MOUSE , T;
DR   Q9QXN4    , MIOX_RAT   , T; Q02198    , MORA_PSEPU , T;
DR   Q8CG09    , MRP1_RAT   , T; Q7G764    , NADO1_ORYSJ, T;
DR   Q7G765    , NADO2_ORYSJ, T; P80508    , PE2R_RABIT , T;
DR   P05980    , PGFS1_BOVIN, T; P52897    , PGFS2_BOVIN, T;
DR   P22045    , PGFS_LEIMA , T; Q4DJ07    , PGFS_TRYCC , T;
DR   P28475    , S6PD_MALDO , T; P0DKI7    , STORR_PAPSO, T;
DR   C5FFQ7    , XYL1_ARTOC , T; A1CRI1    , XYL1_ASPCL , T;
DR   B0XNR0    , XYL1_ASPFC , T; B8N195    , XYL1_ASPFN , T;
DR   Q4WJT9    , XYL1_ASPFU , T; A2Q8B5    , XYL1_ASPNC , T;
DR   Q9P8R5    , XYL1_ASPNG , T; Q2UKD0    , XYL1_ASPOR , T;
DR   Q0CUL0    , XYL1_ASPTN , T; Q8X195    , XYL1_CANBO , T;
DR   Q6Y0Z3    , XYL1_CANPA , T; O74237    , XYL1_CANTE , T;
DR   O13283    , XYL1_CANTR , T; Q5BGA7    , XYL1_EMENI , T;
DR   A1D4E3    , XYL1_NEOFI , T; O94735    , XYL1_PICGU , T;
DR   P31867    , XYL1_PICST , T; Q9P430    , XYL1_SCHSH , T;
DR   P87039    , XYL2_CANTR , T; A3PXS9    , Y1918_MYCSJ, T;
DR   A3PXT0    , Y1919_MYCSJ, T; Q1BAN7    , Y1938_MYCSS, T;
DR   A1UEC5    , Y1984_MYCSK, T; A1UEC6    , Y1985_MYCSK, T;
DR   A0QV10    , Y2408_MYCS2, T; A4TE41    , Y4205_MYCGI, T;
DR   O14088    , YER5_SCHPO , T; P47137    , YJ66_YEAST , T;
DR   Q09632    , YOF5_CAEEL , T; Q12458    , YPR1_YEAST , T;
DR   O34678    , YTBE_BACSU , T;
DR   P49261    , CROB_LEPLU , P; P55804    , DHGP_ASPNG , P;
DR   C9JRZ8    , AK1BF_HUMAN, N; P82809    , AK1CD_MESAU, N;
DR   Q8VC28    , AK1CD_MOUSE, N; Q91WR5    , AK1CL_MOUSE, N;
DR   Q6AYQ2    , AK1CL_RAT  , N; Q5T2L2    , AKCL1_HUMAN, N;
DR   Q96JD6    , AKCL2_HUMAN, N; Q4R802    , AKCL2_MACFA, N;
DR   B8ASB2    , AKR1_ORYSI , N; Q0JE32    , AKR1_ORYSJ , N;
DR   C6TBN2    , AKR1_SOYBN , N; A2XRZ0    , AKR2_ORYSI , N;
DR   Q7XT99    , AKR2_ORYSJ , N; A2XRZ6    , AKR3_ORYSI , N;
DR   Q7XQ45    , AKR3_ORYSJ , N; P77256    , AKRMG_ECOLI, N;
DR   P74308    , AKR_SYNY3  , N; P27800    , ALDX_SPOSA , N;
DR   Q9C5B9    , ALKR1_ARATH, N; Q84M96    , ALKR2_ARATH, N;
DR   O22707    , ALKR3_ARATH, N; Q93ZN2    , ALKR4_ARATH, N;
DR   Q9ASZ9    , ALKR5_ARATH, N; F4HPY8    , ALKR6_ARATH, N;
DR   Q6IMN8    , ALRA_DICDI , N; Q55FL3    , ALRC_DICDI , N;
DR   Q04212    , ARA2_YEAST , N; A9CEY6    , DHGRD_AGRFC, N;
DR   Q2G5J3    , DHGRD_NOVAD, N; P06632    , DKGA_CORSC , N;
DR   Q8X7Z7    , DKGB_ECO57 , N; P30863    , DKGB_ECOLI , N;
DR   Q8Z988    , DKGB_SALTI , N; Q8ZRM7    , DKGB_SALTY , N;
DR   Q8ZH36    , DKGB_YERPE , N; Q52472    , FCDH_PSESP , N;
DR   O81884    , GALDH_ARATH, N; Q0GYU5    , GLD1_HYPJE , N;
DR   P80874    , GS69_BACSU , N; O13848    , I3ACR_SCHPO, N;
DR   P46336    , IOLS_BACSU , N; Q07551    , KAR_YEAST  , N;
DR   P82810    , MORA_RABIT , N; Q3L181    , PERR_RAUSE , N;
DR   Q9GV41    , PGFS_TRYBB , N; O14295    , PLR1_SCHPO , N;
DR   Q06494    , PLR1_YEAST , N; O94521    , PLR2_SCHPO , N;
DR   G4MZI3    , PRD1_PYRO7 , N; Q876L8    , XYL1_HYPJE , N;
DR   P49378    , XYL1_KLULA , N; P78736    , XYL1_PACTA , N;
DR   G4N708    , XYL1_PYRO7 , N; B8ZS00    , Y1669_MYCLB, N;
DR   O69462    , Y1669_MYCLE, N; B2HIJ9    , Y1744_MYCMM, N;
DR   A0PQ11    , Y1987_MYCUA, N; A1T726    , Y2161_MYCVP, N;
DR   A0QV09    , Y2407_MYCS2, N; P9WQA4    , Y2971_MYCTO, N;
DR   P9WQA5    , Y2971_MYCTU, N; A1KMW6    , Y2993_MYCBP, N;
DR   Q7TXI6    , Y2996_MYCBO, N; A5U6Y1    , Y2999_MYCTA, N;
DR   Q73VK6    , Y3007_MYCPA, N; A0QJ99    , Y3816_MYCA1, N;
DR   Q73SC5    , Y4149_MYCPA, N; A0QL30    , Y4483_MYCA1, N;
DR   O42888    , YBN4_SCHPO , N; Q10494    , YDG7_SCHPO , N;
DR   O14125    , YEZB_SCHPO , N; O94315    , YH5B_SCHPO , N;
DR   Q9C1X5    , YKW2_SCHPO , N;
DR   Q42400    , AAP1_ARATH , F; P92934    , AAP6_ARATH , F;
DR   B1MLV9    , ATPFD_MYCA9, F; Q752Q2    , BST1_EREGS , F;
DR   Q96F05    , CK024_HUMAN, F; Q9C6G0    , DEXH4_ARATH, F;
DR   Q2U0Q9    , EIF3C_ASPOR, F; Q0CVT0    , EIF3C_ASPTN, F;
DR   Q0ZB76    , EIF3C_BOMMO, F; Q9ZCZ1    , FAD3_RICPR , F;
DR   Q1HCM0    , FGFP3_MOUSE, F; Q22RG7    , H34_TETTS  , F;
DR   Q7N3S7    , HMUV_PHOLL , F; Q99PI5    , LPIN2_MOUSE, F;
DR   Q3KE48    , MACBH_PSEPF, F; A0A087WXM9, MEIKN_HUMAN, F;
DR   A9IWA4    , MURC_BART1 , F; Q8UIF2    , MUTS_AGRFC , F;
DR   A8I275    , MUTS_AZOC5 , F; Q6G542    , MUTS_BARHE , F;
DR   Q6G0X1    , MUTS_BARQU , F; A9ILT1    , MUTS_BART1 , F;
DR   Q2YNZ0    , MUTS_BRUA2 , F; A6WV86    , MUTS_BRUA4 , F;
DR   Q57FM9    , MUTS_BRUAB , F; A9M792    , MUTS_BRUC2 , F;
DR   Q8YES6    , MUTS_BRUME , F; A5VN83    , MUTS_BRUO2 , F;
DR   B0CIQ5    , MUTS_BRUSI , F; Q8G310    , MUTS_BRUSU , F;
DR   Q11B27    , MUTS_CHESB , F; Q2KD76    , MUTS_RHIEC , F;
DR   Q1MMA5    , MUTS_RHIJ3 , F; Q1K8F6    , NAGS_NEUCR , F;
DR   B2B2C5    , NAGS_PODAN , F; A9KT32    , NIGP_LACP7 , F;
DR   A0A455LLW5, NTND_NECSZ , F; Q8RXH2    , NUP85_ARATH, F;
DR   Q9YBX8    , OFOB2_AERPE, F; Q90941    , PB1_CHICK  , F;
DR   Q86U86    , PB1_HUMAN  , F; O02811    , PI4KA_BOVIN, F;
DR   P42356    , PI4KA_HUMAN, F; E9Q3L2    , PI4KA_MOUSE, F;
DR   O08662    , PI4KA_RAT  , F; Q1J2D0    , PTA_DEIGD  , F;
DR   P95991    , RL13_SACS2 , F; Q6B8S1    , RR18_GRATL , F;
DR   Q1KVT1    , RR18_TETOB , F; P62659    , RS18_THET2 , F;
DR   Q5SLQ0    , RS18_THET8 , F; P80382    , RS18_THETH , F;
DR   A0T0G5    , SECA_PHATC , F; Q045X9    , SYE_LACGA  , F;
DR   Q74L27    , SYE_LACJO  , F; A0RQ93    , TRMB_CAMFF , F;
DR   Q6CSG8    , U507_KLULA , F; A0A024F910, VLMS_LECSP , F;
DR   Q9ZCE0    , XERC_RICPR , F; Q68VT2    , XERC_RICTY , F;
DR   Q6R7C1    , Y109_OSHVF , F; Q8DB14    , Y2014_VIBVU, F;
DR   Q7MIW1    , Y2402_VIBVY, F;
3D   1ABN; 1ADS; 1AE4; 1AFS; 1AH0; 1AH3; 1AH4; 1AZ1; 1AZ2; 1C9W; 1CWN; 1DLA;
3D   1EF3; 1EKO; 1EL3; 1FRB; 1HQT; 1IEI; 1IHI; 1J96; 1JEZ; 1K8C; 1LWI; 1MAR;
3D   1MI3; 1MRQ; 1MZR; 1PWL; 1PWM; 1Q13; 1Q5M; 1R38; 1RAL; 1RY0; 1RY8; 1S1P;
3D   1S1R; 1S2A; 1S2C; 1SM9; 1T40; 1T41; 1US0; 1X96; 1X97; 1X98; 1XF0; 1XJB;
3D   1YE4; 1YE6; 1Z3N; 1Z89; 1Z8A; 1Z9A; 1ZQ5; 1ZUA; 2ACQ; 2ACR; 2ACS; 2ACU;
3D   2AGT; 2ALR; 2BGQ; 2BGS; 2DUX; 2DUZ; 2DV0; 2F2K; 2F38; 2FGB; 2FVL; 2FZ8;
3D   2FZ9; 2FZB; 2FZD; 2HDJ; 2HUO; 2HV5; 2HVN; 2HVO; 2I16; 2I17; 2IKG; 2IKH;
3D   2IKI; 2IKJ; 2INE; 2INZ; 2IPJ; 2IPW; 2IQ0; 2IQD; 2IS7; 2ISF; 2J8T; 2NVC;
3D   2NVD; 2PD5; 2PD9; 2PDB; 2PDC; 2PDF; 2PDG; 2PDH; 2PDI; 2PDJ; 2PDK; 2PDL;
3D   2PDM; 2PDN; 2PDP; 2PDQ; 2PDU; 2PDW; 2PDX; 2PDY; 2PEV; 2PF8; 2PFH; 2PZN;
3D   2QXW; 2R24; 2VDG; 3B3D; 3BCJ; 3BUR; 3BUV; 3BV7; 3BXD; 3C3U; 3CAQ; 3CAS;
3D   3CAV; 3CMF; 3COT; 3CV7; 3D3F; 3DN5; 3DOP; 3F7J; 3FX4; 3G1R; 3G5E; 3GHR;
3D   3GHS; 3GHT; 3GHU; 3GUG; 3H4G; 3H7R; 3H7U; 3LBO; 3LD5; 3LEN; 3LEP; 3LQG;
3D   3LQL; 3LZ3; 3LZ5; 3M0I; 3M4H; 3M64; 3MB9; 3MC5; 3NTY; 3ONB; 3ONC; 3P2V;
3D   3Q65; 3Q67; 3R43; 3R58; 3R6I; 3R7M; 3R8G; 3R8H; 3R94; 3RX2; 3RX3; 3RX4;
3D   3S3G; 3T42; 3U2C; 3UFY; 3UG8; 3UGR; 3UWE; 3UZW; 3UZX; 3UZY; 3UZZ; 3V35;
3D   3V36; 3WCZ; 4DBS; 4DBU; 4DBW; 4DZ5; 4F40; 4FA3; 4FAL; 4FAM; 4FZI; 4G5D;
3D   4GA8; 4GAB; 4GAC; 4GCA; 4GIE; 4GQ0; 4GQG; 4H7C; 4HMN; 4I5X; 4ICC; 4IGS;
3D   4IJC; 4IJR; 4JIH; 4JII; 4JIR; 4JQ1; 4JQ2; 4JQ3; 4JQ4; 4JQA; 4JTQ; 4JTR;
3D   4L1W; 4L1X; 4LAU; 4LAZ; 4LB3; 4LB4; 4LBR; 4LBS; 4NKC; 4PR4; 4PRR; 4PRT;
3D   4PUU; 4PUW; 4Q7B; 4QBX; 4QR6; 4QX4; 4QXI; 4RPQ; 4WDT; 4WDU; 4WDW; 4WDX;
3D   4WEV; 4WRH; 4XO6; 4XO7; 4XVD; 4XVE; 4XZH; 4XZI; 4XZL; 4XZM; 4XZN; 4YS1;
3D   4YU1; 4YVP; 4YVV; 4YVX; 4ZFC; 5HA7; 5HNT; 5HNU; 5LIK; 5LIU; 5LIW; 5LIX;
3D   5LIY; 5M2F; 5OU0; 5OUJ; 5OUK; 5Y7N; 5Z6T; 5Z6U; 6A7A; 6A7B; 6F2U; 6F78;
3D   6F7R; 6F81; 6F82; 6F84; 6F8O; 6GXK; 6IJX; 6SYW; 6T27; 6T3P; 6T5G; 6T7Q;
3D   6TD8; 6TUC; 6TUF; 6TXP; 6XUM; 6Y03; 6Y1P; 7C7F; 7C7G; 7C7H; 7MBF; 7WQM;
3D   7WQR; 7WQS; 7X3L; 7X3M; 7X3O; 8A4N; 8AE9; 8AQG; 8AQP; 8AUU; 8B34; 8B3N;
3D   8B3R; 8B66; 8BBS; 8BJL; 8I0C;
DO   PDOC00061;
//